SynthesisObesity surgery2026
Comparative Outcomes of Roux-en-Y Gastric Bypass and Fundoplication in Adults Living with Obesity and GERD: A Systematic Review and Meta-analysis.
Synthesis in Obesity surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundGERD is a common comorbidity in patients with obesity, and its high incidence may be related to the increased intra-abdominal pressure caused by the accumulation of abdominal fat. Fundoplication is commonly used as a surgical procedure for treating GERD, but the recurrence rate of GERD is elevated in patients with obesity. RYGB is one of the most common metabolic bariatric surgeries which is safe and effective in patients with obesity.
objectivesThe aim of this study is to compare the effects and safety of RYGB and fundoplication in patients with obesity with GERD.
methodsSystematic searches were conducted in databases such as PubMed, the Cochrane Library, Web of Science, EMBASE and Scopus for English-language studies comparing the therapeutic effects of RYGB and fundoplication in patients with GERD.
resultsEleven studies involving 1,134 patients were included, with 485 (42.8%) in RYGB group and 649 (57.2%) in fundoplication (FUN) group. In the overall analysis and five subgroups (as primary surgery; as revisional surgery; without hiatal hernia repair; based on BMI and follow up duration), the results showed no significant differences for GERD symptom control between groups. In overall analysis, preoperative BMI and BMI reductions in the RYGB group were significantly higher, while FUN group had a higher preoperative HH rate. RYGB also resulted in a longer operation time, and higher complication rate in overall analysis. However, no differences in complication rate were observed during subgroup analyse.
conclusionsBased on available data, our study indicated both RYGB and FUN appear to offer considerable improvement in GERD symptoms for patients with obesity and GERD. RYGB represents a viable consideration for these patients. However, the conclusion of GERD improvement is primarily based on patient-reported symptom improvement, and a critical limitation is the lack of objective GERD measures (e.g., pH monitoring) in the included studies. Furthermore, all included studies were observational, thus, future prospective trials are necessary to validate these findings.
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