ReviewPflugers Archiv : European journal of physiology2025
From chaos to control: Nobel insights in regulatory T cells and immune tolerance.
Review in Pflugers Archiv : European journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 2025 Nobel prize in Medicine or Physiology was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for unravelling the basis of peripheral immune tolerance: regulatory T (Treg) cells. Treg cells are a subset of CD4+ T helper cells characterized by the expression of the transcription factor Foxp3 and the surface receptor CD25 (IL-2 receptor alpha subunit) and are key for maintaining immune homeostasis and preventing autoimmunity. In this minireview, we trace the discovery of Treg cells, their phenotype and function and how these findings are employed in generating safer and more efficient therapies for autoimmune diseases and cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.