Evidence map›Paper›PMID 41366165›Full record

ArticleAnnals of surgical oncology2026

The Role of Primary Tumor Resection in Surgical Management of Asymptomatic Metastatic PNETs: A Retrospective Single-Center Study.

Vanja Podrascanin, Markus Ammann, Hallbera Gudmundsdottir, Yawen Dong, Cornelius A Thiels, Susanne G Warner, Mark J Truty, Michael L Kendrick, Rory L Smoot, Rodney F Pommier and 4 more

Abstract read
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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Vanja PodrascaninDepartment of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.
Markus AmmannDepartment of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.
Hallbera GudmundsdottirDepartment of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.
Yawen DongDepartment of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.
Cornelius A ThielsDepartment of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.
Susanne G WarnerDepartment of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.
Mark J TrutyDepartment of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.
Michael L KendrickDepartment of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.
Rory L SmootDepartment of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.
Rodney F PommierDivision of Surgical Oncology, Department of Surgery, Oregon Health and Science University, Portland, OR, USA.
Kaiya KozumaDivision of Surgical Oncology, Department of Surgery, Oregon Health and Science University, Portland, OR, USA.
Thorvardur R HalfdanarsonDivision of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, MN, USA.
David M NagorneyDepartment of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.
Patrick P StarlingerDepartment of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, USA. starlinger.patrick@mayo.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCytoreductive hepatectomy has repeatedly been reported to improve prognosis in pancreatic neuroendocrine tumor liver metastasis (PNETLM). However, whether primary tumor resection impacts prognosis in asymptomatic synchronously metastasized pancreatic neuroendocrine tumors (PNETs) remains elusive. We aimed to evaluate the prognostic impact of primary tumor resection in patients undergoing cytoreductive hepatectomy for PNETLM. PATIENTS AND

methodsThis retrospective single-center study analyzed patients who underwent hepatectomy for pancreatic PNETLM between January 2000 and December 2020. Patients were categorized according to surgical approaches: cytoreductive hepatectomy without primary tumor resection at any time (non-PTR), cytoreductive hepatectomy and pancreaticoduodenectomy (PD), or cytoreductive hepatectomy and distal pancreatectomy (DP). Surgical outcomes and risk factors for overall survival (OS) were assessed.

resultsA total of 118 patients with asymptomatic PNETs and synchronous liver metastases were analyzed. The median OS was 10 years (95% CI: 6.5-12), with no significant differences across surgical approach regarding primary tumor resection (non-PTR: 10 years; PD: 8 years; DP: 9.5 years; p = 0.589). Survival rates at 5 years were 66.7% in non-PTR, 62.3% in PD, and 65.8% in DP respectively. PFS was similar between groups (p = 0.301). Extrahepatic disease and liver lesion count were significant predictors of progression-free survival in univariate analysis (p < 0.050), while resection of the primary tumor had no significant impact (p = 0.749)

conclusionsPNET primary tumor resection was not associated with improved long-term outcomes in PNETLM patients after cytoreductive hepatectomy. This should spark interest if refraining from primary resection might be an option in selected patients considering the risks associated with pancreatic surgery.

Indexed as

Cytoreduction Surgical ProceduresHepatectomyLiver NeoplasmsNeuroendocrine TumorsPancreatectomyPancreatic NeoplasmsPancreaticoduodenectomyAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesBiliary tree contaminationCytoreductive hepatectomyNeuroendocrine liver metastasesNeuroendocrine pancreas tumorPrimary tumor resection

Identifiers

PMID41366165

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.