ReviewInternational journal of clinical oncology2026
Is neoadjuvant therapy necessary for resectable pancreatic cancer? A review of randomized controlled trials to date: a narrative review.
Review in International journal of clinical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perioperative systemic therapy, administered either preoperatively (neoadjuvant therapy) or postoperatively (adjuvant therapy), has been considered a strategy to improve the long-term prognosis of pancreatic cancer. While adjuvant therapy following resection has demonstrated a clear long-term prognostic benefit, the significance of neoadjuvant therapy remains uncertain. This manuscript reviews previously published randomized controlled trials and provides a scientific discussion on the value of neoadjuvant therapy. To date, eight phase II or phase III randomized controlled trials have been conducted, but their results have been inconsistent. Clear evidence has not been established due to several factors, including differences in chemotherapy agents used across trials, variations in primary endpoints, and the inclusion of borderline resectable pancreatic cancer cases. Ongoing randomized controlled trials are expected to clarify the role of neoadjuvant therapy in resectable pancreatic cancer.
Indexed as
Identifiers
41366146What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.