ReviewNeuropsychology review2025
Brain Functional and Structural Changes of Breast Cancer After Chemotherapy: A Systematic Review and Meta-analysis.
Review in Neuropsychology review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Working Memory Impairment Induced by Chemotherapy-A Narrative Review.Brain sciences · 2026Review
- Poor brain reserve increases mortality risk in glioblastoma.Neuro-oncology advancesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Chemotherapy, a standard treatment for breast cancer (BC), is known to exert neurotoxic effects on the central nervous system. The aim of this study was to identify consistent patterns of brain structural and functional alterations linked to chemotherapy in patients with BC and explore potential clinical correlates, such as age, education, and treatment characteristics. Data from 29 neuroimaging investigations, including structural magnetic resonance imaging (MRI), diffusion tensor imaging, and resting-state functional MRI, were analyzed using a coordinate-based meta-analysis. The results revealed significant gray matter reductions in regions including the orbitofrontal cortex, anterior cingulate cortex, insula, cerebellum, and rolandic operculum, alongside functional hypoactivation in the rolandic operculum and insula, when comparing chemotherapy-treated patients to chemotherapy-naive controls. These findings suggest that chemotherapy primarily affects regions involved in cognitive and emotional regulation. A higher education level may serve as a protective factor, possibly reflecting greater gray matter structural integrity, that mitigates chemotherapy-related neurotoxic effects. This study may offer insights into the underlying neural mechanisms of chemotherapy-related cognitive changes. Further research should investigate treatment-specific effects and long-term outcomes.
Indexed as
Identifiers
41366134What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.