Evidence map›Paper›PMID 41366092›Full record

ReviewSpinal cord2026

Spinal cord vascular autoregulation: key concepts and opportunities to improve management.

Denis Routkevitch, Kelly Jiang, Carly Weber-Levine, A Daniel Davidar, Nitish V Thakor, C David Mintz, Kathryn Rosenblatt, Romergryko G Geocadin, Nicholas Theodore

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Spinal cord, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Denis RoutkevitchDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA. droutke1@jhmi.edu.ORCID 0000-0002-7144-6347
Kelly JiangDepartment of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Carly Weber-LevineDepartment of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
A Daniel DavidarDepartment of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Nitish V ThakorDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
C David MintzDepartment of Anesthesia and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
Kathryn RosenblattDepartment of Anesthesia and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-9677-7997
Romergryko G GeocadinDepartment of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Nicholas TheodoreDepartment of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-5355-2683

Funding

Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
Consequences of Cardiac Arrest: Brain InjuryR01HL071568 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI GEOCADIN, ROMERGRYKO, THAKOR, NITISH VYOMESH · 2003 to 2022
$8.4M
Translational Technologies for Ameliorating Brain InjuryR01HL139158 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KANNAN, SUJATHA, THAKOR, NITISH VYOMESH · 2018 to 2021
$2.1M
Spinal Cord Injury: A Cardiovascular Perspective using UltrasoundF30HL168823 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Denis Routkevitch · 2024 to 2026
$164k
DOD | Defense Advanced Research Projects Agency (DARPA) N660012024075NHLBI NIH HHS F30 HL168823NHLBI NIH HHS R01 HL071568NHLBI NIH HHS R01 HL139158NIGMS NIH HHS T32 GM136577
6 · The paper itself

Abstract

STUDY

designNarrative review.

objectivesVascular autoregulation in the central nervous system (CNS) maintains appropriate perfusion in the context of changing blood pressure. Impaired autoregulation in various diseases often contributes to their pathophysiology. While this mechanism is well characterized in the brain, it remains understudied in the spinal cord, limiting evidence-based blood pressure management in spinal cord pathology. In this review, we summarize the current understanding of spinal cord autoregulation, highlight advancements in cerebral autoregulation, and offer a framework for its clinical application in spinal cord care.

methodsA literature search was conducted comparing preclinical evidence of spinal cord autoregulation with current clinical practices in the brain.

resultsAlthough autoregulation has been recognized in the spinal cord, it has been mostly measured in animals, and its clinical impact has been limited. In contrast, cerebral autoregulation has influenced patient care through continuous monitoring of dynamic autoregulation and clinical trials using personalized blood pressure targets. These innovations require measurement of blood flow or a surrogate, which is performed infrequently in the cord. Furthermore, confounding variables, such as arterial CO

conclusionsSpinal cord autoregulation is an essential variable in neurology and neurosurgery. A better understanding of this process could improve outcomes in various conditions, including traumatic injury, ischemic injury, and other spinal diseases. As spinal cord blood flow measurement technologies improve, there is a growing opportunity to apply autoregulation to direct patient care.

Indexed as

HomeostasisSpinal CordSpinal Cord InjuriesAnimalsBlood PressureCerebrovascular CirculationHumans

Identifiers

PMID41366092
PMCPMC12799489

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.