Evidence map›Paper›PMID 41365974›Full record

ArticleScientific reports2025

Treadmill exercise ameliorates atherogenesis and vascular inflammation in ApoE

Wenhuang Guo, Jinyun Wang, Zaoshang Chang, Shuo Lin, Guangyuan Sha, Shen Wang, Junhao Huang, Min Hu, Jingbo Xia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wenhuang Guo *Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, 510500, China.
Jinyun Wang *Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, 510500, China.
Zaoshang Chang *Department of Physiology, Shaoyang University, Shaoyang, China.
Shuo LinGuangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, 510500, China.
Guangyuan ShaGuangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, 510500, China.
Shen WangGuangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, 510500, China.
Junhao HuangGuangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, 510500, China. junhaohuang2006@hotmail.com.
Min HuGuangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, 510500, China. whoomin@aliyun.com.
Jingbo XiaGuangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, 510500, China. xiajb@gzsport.edu.cn.ORCID http://orcid.org/0000-0003-3293-4812

Funding

Characteristic Innovation Project of Guangdong Provincial Education Department 2024KTSCX128Guangzhou Basic Research Plan, Basic and Applied Basic Research Project SL2022A04J00488Key Scientific Research Project of Hunan Provincial Department of Education 22A0528National Natural Science Foundation of China 82202815
6 · The paper itself

Abstract

Regular exercise training has been shown to significantly decrease atherosclerosis (AS) related mortality and hospitalization rates. Recent research has identified that circulating exosome-derived microRNAs (miRNAs) are closely related to the progression of AS through intercellular communication. But the role of exosome-derived miRNAs in exercise-mediated protection remains to be explored. This study proposes that exercise may ameliorate vascular dysfunction and plaque formation associated with AS by modulating the expression profile of exosomal miRNAs. In this study, ApoE

Indexed as

Apolipoproteins EAtherosclerosisExosomesMicroRNAsPhysical Conditioning, AnimalAnimalsInflammationMaleMiceMice, KnockoutMice, Knockout, ApoETissue Inhibitor of Metalloproteinase-3Apolipoproteins EMicroRNAsmirnlet7 microRNA, mouseTissue Inhibitor of Metalloproteinase-3Atherosclerosislet-7c-5pTimp-3Treadmill exerciseVascular inflammation

Identifiers

PMID41365974
PMCPMC12775415

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.