ArticleScientific reports2025
Propolis reduced the radiation-induced bystander effect in rat liver exposed to total head irradiation.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Propolis and Caffeic Acid Phenethyl Ester Attenuate Oxidative and Nitrosative Stress in Rat Kidney Tissue After Cranial Irradiation.Life (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the realm of radiation oncology, the observation of the radiation-induced bystander effect (RIBE) has raised concerns about off-target tissue effects caused by radiation. The concept of RIBE encompasses the response of non-irradiated tissue to radiation exposure. This study investigated the impact of cranial irradiation on oxidative/nitrosative stress and inflammatory responses in liver tissue. Thirty-two male Sprague-Dawley rats were divided into four groups: sham, irradiation (IR), propolis plus IR, and propolis control. The IR group received an initial 1 ml oral dose of saline via an orogastric tube. Subsequently, the IR and IR plus propolis groups received a single dose of 5 Gy (Gy) gamma irradiation to the entire cranium. The IR plus Propolis Group received propolis (80 mg kg/day) via an orogastric tube one hour before IR, and this procedure was continued daily for 10 days. Liver tissue was analyzed for biochemical parameters at the study's conclusion. In the IR group, total antioxidant status (TAS), total sulfhydryl groups (-SH) levels, paraoxonase (PON) and arylesterase (ARYL) activities were significantly diminished compared to all other groups, while nitric oxide synthase (NOS) activity, nitric oxide (NO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.