Evidence map›Paper›PMID 41365900›Full record

ArticleNature communications2025

Hierarchical core-shell DNA condensates enable programmable information storage and encryption.

Likang Chu, Liqi Wan, Haixia Wang, Peng Wang, Linyi Deng, Yuan Gao, Pei Guo, Lei He, Da Han

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Spatially Encoded Protocell Network for Non-Cascaded Parallel Biocomputation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Article
  5. The Polymers of Life: Exploring Cellular Function Through Polymer Concepts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Likang ChuThe Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Liqi WanThe Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.ORCID http://orcid.org/0000-0003-3663-2678
Haixia WangThe Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Peng WangThe Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Linyi DengInstitute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.ORCID http://orcid.org/0009-0003-4817-0359
Yuan GaoInstitute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Pei GuoThe Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.ORCID http://orcid.org/0000-0001-7760-5786
Lei HeThe Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China. helei@hnu.edu.cn.ORCID http://orcid.org/0000-0003-2820-0162
Da HanThe Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China. dahan@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-0804-2964

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32341017
6 · The paper itself

Abstract

Utilizing DNA's molecular programmability, massive parallelism, and minimal energy requirements, it emerges as a transformative medium for secure data storage and encryption. However, practical implementation is limited by technical challenges, particularly the development of robust, programmable systems for flexible data encoding, precise molecular operations, and reliable encryption. Here, we present a molecular information storage and encryption platform that integrates hierarchical core-shell DNA condensates with biomolecular computing networks. It allows programmable and rapid execution of core operations such as information encoding, erasure, rewriting, replication, and repair within readily accessible and readable DNA-based condensates. Moreover, programmable biomolecular computing circuits endowed the system with unprecedented encryption capabilities, including multi-level logic encryption, time-dependent dynamic encryption, living system-driven encryption and fine-grained access control of information. Together, this work represents a meaningful advancement in molecular information storage and encryption, with notable advantages in dynamic editability and system scalability.

Indexed as

Computer SecurityComputers, MolecularDNAInformation Storage and RetrievalDNA

Identifiers

PMID41365900
PMCPMC12796251

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.