Evidence map›Paper›PMID 41365615›Full record

ArticleContact dermatitis2026

Anogenital Contact Dermatitis in Spain: A REIDAC Study of Patients Undergoing Patch Testing in 2019-2024.

Mercè Grau-Pérez, Pedro Mercader-García, Ana María Giménez-Arnau, Tatiana Sanz-Sánchez, Violeta Zaragoza Ninet, Susana Córdoba Guijarro, Francisco Javier Miquel Miquel, Juan Francisco Silvestre Salvador, Ricardo González-Pérez, Inmaculada Ruíz González and 20 more

Abstract read
In one paragraph

Article in Contact dermatitis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Mercè Grau-PérezDepartment of Dermatology, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, Madrid, Spain.ORCID https://orcid.org/0000-0002-7628-3495
Pedro Mercader-GarcíaDepartment of Dermatology, Hospital General Universitario José María Morales Meseguer, Murcia, Spain.
Ana María Giménez-ArnauDepartment of Dermatology, Hospital del Mar Research Institute, Universitat Pompeu Fabra, Barcelona, Spain.
Tatiana Sanz-SánchezDepartment of Dermatology, Hospital Universitario Infanta Sofía, European University of Madrid, Madrid, Spain.
Violeta Zaragoza NinetDepartment of Dermatology, Hospital General Universitario de Valencia, Valencia, Spain.
Susana Córdoba GuijarroDepartment of Dermatology, Hospital Universitario de Fuenlabrada, Madrid, Spain.
Francisco Javier Miquel MiquelDepartment of Dermatology, Hospital Universitario Arnau de Vilanova, Valencia, Spain.
Juan Francisco Silvestre SalvadorDepartment of Dermatology, Hospital General Universitario Dr Balmis, ISABIAL, Alicante, Spain.
Ricardo González-PérezDepartment of Dermatology, Hospital Universitario Araba, Universidad del País Vasco, Vitoria, Spain.
Inmaculada Ruíz GonzálezDepartment of Dermatology, Complejo Asistencial Universitario de León, León, Spain.
Esther Serra BaldrichDepartment of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
José Manuel CarrascosaDepartment of Dermatology, Hospital Universitario Germans Trias i Pujol, IGTP, Universitat Autònoma de Barcelona, Barcelona, Spain.
Francisco Javier Ortiz de FrutosDepartment of Dermatology, Hospital Universitario 12 de Octubre, Madrid, Spain.
Mercedes Rodríguez SernaDepartment of Dermatology, Hospital Universitario La Fe, Valencia, Spain.
María Elena Gatica OrtegaDepartment of Dermatology, Complejo Hospitalario Universitario de Toledo, Toledo, Spain.
Carmen Paredes SuárezDepartment of Dermatology, Complejo Hospitalario Universitario Santiago de Compostela, Santiago de Compostela, Spain.
Francisco José Navarro TriviñoDepartment of Dermatology, Hospital Universitario San Cecilio, Granada, Spain.ORCID https://orcid.org/0000-0002-5454-3671
Pablo ChicharroDepartment of Dermatology, Hospital Universitario de La Princesa, Madrid, Spain.
Marta AndreuDepartment of Dermatology, Hospital Universitario Fundación Alcorcón, Madrid, Spain.
Araceli Sánchez GiloDepartment of Dermatology, Hospital Universitario Rey Juan Carlos, Móstoles, Spain.
José Juan Pereyra RodríguezDepartment of Dermatology, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain.
María Antonia Pastor NietoDepartment of Dermatology, Hospital Universitario Fundacion Jiménez Díaz, Madrid, Spain.
Gemma Melé-NinotDepartment of Dermatology, Hospital Universitario Sagrat Cor, Barcelona, Spain.ORCID https://orcid.org/0000-0003-0365-0634
Paloma Sánchez-Pedreño GuillénDepartment of Dermatology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
Enrique Gómez de la FuenteDepartment of Dermatology, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Marta Elosua-GonzálezDepartment of Dermatology, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, Madrid, Spain.
Mónica Munera-CamposDepartment of Dermatology, Hospital Universitario Germans Trias i Pujol, IGTP, Universitat Autònoma de Barcelona, Barcelona, Spain.
Fátima Tous RomeroDepartment of Dermatology, Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID https://orcid.org/0000-0002-3904-3396
Miguel Ángel DescalzoResearch Unit, Academia Española de Dermatología y Venereología (AEDV), Madrid, Spain.
Leopoldo BorregoDepartment of Dermatology, Hospital Universitario Insular de Gran Canaria, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.

Funding

Agencia Española de Medicamentos y Productos SanitariosFundación Piel SanaGlaxoSmithKlineLEO PharmaNovartisSanofi
6 · The paper itself

Abstract

backgroundThe REIDAC (Spanish Registry for Research in Contact Dermatitis) conducts nationwide epidemiological surveillance of contact dermatitis in Spain. Anogenital involvement within REIDAC has not been previously studied.

objectivesTo describe the most common diagnoses and update relevant allergens in patients with anogenital lesions referred for patch testing.

methodsWe analysed patients who underwent patch testing within REIDAC from 2019 to 2024. Patients were classified into three groups: (G1) exclusively anogenital lesions, (G2) no anogenital involvement and (G3) both anogenital and non-anogenital lesions. Sensitisation and relevance were assessed.

resultsAmong 18 291 patients, 116 (0.6%) had exclusively anogenital lesions, 17 576 (96.1%) had no anogenital involvement and 599 (3.3%) had both. G1 patients were more likely to have at least one positive reaction (91.4%), a current relevant reaction (53.4%, diagnosed with allergic contact dermatitis, ACD) and to be polysensitised compared to other groups (p < 0.001). 14.5% of anogenital ACD identified cases were not identified by the Spanish baseline series. Fragrances, preservatives, topical anaesthetics and steroids were the leading relevant allergens. Benzisothiazolinone, sodium metabisulfite and propolis emerged as new sensitisers.

conclusionACD was highly prevalent among patients with anogenital lesions referred for patch testing. The threshold for patch testing in these patients may need reconsideration.

Indexed as

Dermatitis, Allergic ContactGenital Diseases, FemaleGenital Diseases, MaleAdolescentAdultAgedAllergensFemaleHumansMaleMiddle AgedPatch TestsRegistriesSpainYoung AdultAllergensallergic contact dermatitisallergyanogenitaldermatologyenvironmental medicineepidemiologygenital diseases

Identifiers

PMID41365615
PMCPMC12872340

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.