Evidence map›Paper›PMID 41365584›Full record

ArticleBMJ open2025

Mixed-methods study exploring medium to longer-term outcomes following selective dorsal rhizotomy in ambulatory children w

Deepti Chugh, Cherry Kilbride, Hortensia Gimeno, Kristian Aquilina, Lucy Alderson, Tim Theologis, Eleanor Main

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06518889 (Medium to Long-term Outcomes After Selective Dorsal Rhizotomy in Ambulatory Children and Young People With Cerebral Palsy), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06518889 unknown statusnot on this map

Medium to Long-term Outcomes After Selective Dorsal Rhizotomy in Ambulatory Children and Young People With Cerebral Palsy: A Mixed-methods Study

TypeobservationalSponsorGreat Ormond Street Hospital for Children NHS Foundation TrustRan2024 to 2026Enrolled90ConditionsCerebral PalsyArmsSelective Dorsal Rhizotomy
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Deepti ChughPhysiotherapy, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK deepti.chugh@gosh.nhs.uk.ORCID http://orcid.org/0000-0002-1002-0334
Cherry KilbrideHealth Sciences, Brunel University London, Uxbridge, UK.ORCID http://orcid.org/0000-0002-2045-1883
Hortensia GimenoQueen Mary University of London, London, UK.
Kristian AquilinaNeurosurgery, Great Ormond Street Hospital For Children NHS Foundation Trust, London, UK.
Lucy AldersonPhysiotheray, ORCHID, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Tim TheologisNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Eleanor MainPhysiotherapy, III, University College London Great Ormond Street Institute of Child Health, London, UK.ORCID http://orcid.org/0000-0002-9739-3167

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSelective dorsal rhizotomy (SDR) is one of the treatment options available for spasticity management in ambulatory children and young people with cerebral palsy (CYPwCP). Although improvements in gross motor function one to two years after surgery have been established, evidence of longer-term benefit requires further investigation. Given the irreversible nature of SDR and the increased rehabilitation commitments required from families and clinicians, providing evidence of longer-term benefits is essential to support their decision-making. This study aims to investigate medium (3-5 years) and long-term (6-10 years) SDR outcomes in ambulatory children with CP and how SDR affects families' lives over time. METHODS AND ANALYSIS: This is a convergent parallel mixed-methods study using the International Classification of Functioning, Disability and Health as a theoretical framework. The study aims to recruit 90 CYPwCP participants, who had SDR at a tertiary hospital in the UK when aged between 3 and 14 years. Participants (parents and CYPwCP) will be invited to complete an online survey and attend the hospital for one follow-up visit 3 or more years after SDR. Comparisons will be made with existing data on objective measures and parent-reported outcomes collected in clinical practice at baseline, 6, 12 and 24 months to understand the trajectory of changes. Semistructured interviews will be conducted with 18-20 parents/carers and 25-30 CYPwCP to understand their perspectives on the outcomes of SDR compared with their prior expectations. The Framework Method will be used to analyse qualitative data both inductively and deductively. Qualitative and quantitative study data will be integrated using joint displays. ETHICS AND DISSEMINATION: Ethical approval has been obtained through the Coventry and Warwick Research and Ethics Committee (24/WM/0078). Findings will be shared through international conferences, peer-reviewed journals, social media and dissemination events for families and CYP. TRIAL REGISTRATION NUMBER: NCT06518889.

Indexed as

Cerebral PalsyMuscle SpasticityRhizotomyAdolescentChildChild, PreschoolFemaleHumansMaleObservational Studies as TopicTertiary Care CentersTreatment OutcomeUnited KingdomChildPaediatric neurosurgeryPatient Reported Outcome MeasuresQUALITATIVE RESEARCHREHABILITATION MEDICINE

Identifiers

PMID41365584
PMCPMC12699567

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.