Evidence map›Paper›PMID 41365502›Full record

ArticleACS applied materials & interfaces2025

Photodynamic Antibacterial Nanofibers with Tunable Pro- and Antioxidant Activity via N,S-Doped Carbon Quantum Dots for Corneal Tissue Engineering.

Roksana Kurpanik, Anna Ścisłowska-Czarnecka, Zofia Kucia, Agnieszka Lechowska-Liszka, Nikola Lenar, Agnieszka Różycka, Marcin Sarewicz, Grzegorz Szewczyk, Ewa Stodolak-Zych

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In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Roksana KurpanikDepartment of Biomaterials and Composites, Faculty of Materials Science and Ceramics, AGH University of Krakow, Krakow 30-059, Poland.ORCID 0000-0002-7943-7509
Anna Ścisłowska-CzarneckaDepartment of Applied Cosmetology, University of Physical Education, Krakow 31-571, Poland.
Zofia KuciaDepartment of Silicate Chemistry and Macromolecular Compounds, Faculty of Materials Science and Ceramics, AGH University of Krakow, Krakow 30-059, Poland.
Agnieszka Lechowska-LiszkaDepartment of Applied Cosmetology, University of Physical Education, Krakow 31-571, Poland.
Nikola LenarDepartment of Analytical Chemistry and Biochemistry, Faculty of Materials Science and Ceramics, AGH University of Krakow, Krakow 30-059, Poland.
Agnieszka RóżyckaDepartment of Building Materials Technology, Faculty of Materials Science and Ceramics, AGH University of Krakow, Krakow 30-059, Poland.
Marcin SarewiczDepartment of Molecular Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow 31-387, Poland.
Grzegorz SzewczykDepartment of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow 31-387, Poland.
Ewa Stodolak-ZychDepartment of Biomaterials and Composites, Faculty of Materials Science and Ceramics, AGH University of Krakow, Krakow 30-059, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic resistance poses a critical challenge in ocular medicine, where treatments must combine antibacterial potency with tissue compatibility. Electrospun core-shell nanofibers offer an attractive solution for ocular applications as they provide a biomimetic extracellular matrix structure with controlled drug release and surface functionality. In this work, polycaprolactone (PCL) was used as the mechanically robust, biodegradable core, while polyvinylpyrrolidone (PVP) formed a hydrophilic shell to enhance wettability and ocular compatibility. The nanofibers were further functionalized with N,S-doped carbon quantum dots, exhibiting light-switchable redox behavior. Compositional and spectroscopic analyses revealed that N,S-doped CQDs possessed a significantly narrowed bandgap (3.14 eV) relative to cysteine- and tryptophan-derived CQDs, attributable to heteroatom-induced defect states and the formation of π-π conjugated domains, confirmed by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FT-IR). XPS measurements showed valence band energies suitable for superoxide generation under illumination, consistent with the reported redox potentials. As a result, illuminated nanofibers produced reactive oxygen species (ROS), reducing

Indexed as

Anti-Bacterial AgentsAntioxidantsCorneaNanofibersQuantum DotsTissue EngineeringCarbonEscherichia coliHumansPhotochemotherapyPolyestersReactive Oxygen SpeciesStaphylococcus aureusAnti-Bacterial AgentsAntioxidantsCarbonpolycaprolactonePolyestersReactive Oxygen Speciesantibacterial photodynamic inactivationcarbon quantum dotscore−shell nanofiberscornea regenerationredox-active biomaterials

Identifiers

PMID41365502
PMCPMC12754744

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.