Evidence map›Paper›PMID 41365296›Full record

ArticleCell2026

Biomaterial-minimalistic photoactivated bioprinting of cell-dense tissues.

Mian Wang, Wanlu Li, Jin Hao, Ling Cai, Xuan Mei, Regina Sanchez Flores, Penélope Cerón Castillo, Carlos Ezio Garciamendez-Mijares, Xuan Mu, Xiao Kuang and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Mian WangDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.
Wanlu LiDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.
Jin HaoDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ling CaiDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.
Xuan MeiDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.
Regina Sanchez FloresDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.
Penélope Cerón CastilloDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.
Carlos Ezio Garciamendez-MijaresDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.
Xuan MuDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.
Xiao KuangDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.
Xianbin YuDepartment of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.
Jugal Kishore SahooDepartment of Biomedical Engineering, Tufts University, Medford, MA, USA.
Guosheng TangDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.
Zeyu LuoDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.
Guillermo WellsDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.
Zhongmin LiuTranslational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Alfredo Quiñones-HinojosaDepartments of Neurosurgery, Oncology, and Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Kevin EgganDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Shaorong GaoShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Yu Shrike ZhangDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: yszhang@bwh.harvard.edu.

Funding

High-Throughput Volumetric Photoacoustic Imaging of Living Vascularized OrganoidsR01EB028143 · NIBIB · DUKE UNIVERSITY · PI YAO, JUNJIE · 2019 to 2022
$2.0M
A Bioprinted Volumetric Model of Vascularized GlioblastomaR01CA282451 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI Kaisorn Lee Chaichana, Y. Shrike Zhang · 2023 to 2026
$1.7M
Recapitulating Ductal Carcinoma on a Chip for Personalized Breast Cancer TherapyR00CA201603 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, Y. SHRIKE · 2019 to 2021
$747k
Multiscale Stereolithogrphic Bioprinting of Stage-Matching Vascularized Tumor ModelsR21EB025270 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, Y. SHRIKE · 2018 to 2020
$726k
Development of An Optoelectronically Active BioinkR21EB030257 · NIBIB · UNIVERSITY OF HOUSTON · PI YU, CUNJIANG · 2020 to 2020
$694k
Modeling Sex-Specific Cardiac Hypertrophy-on-a-ChipR21HL168656 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MAHARJAN, SUSHILA, ZHANG, Y. SHRIKE · 2024 to 2025
$492k
NCI NIH HHS R00 CA201603NCI NIH HHS R01 CA282451NHLBI NIH HHS R21 HL168656NIBIB NIH HHS R01 EB028143NIBIB NIH HHS R21 EB025270NIBIB NIH HHS R21 EB030257
6 · The paper itself

Abstract

Conventional hydrogel-based bioprinting methods often suffer from insufficient cell densities, which may limit crucial cell-cell interactions and impair overall tissue functions. Here, we present an approach that modifies cell membranes with acrylate bonds, allowing living cells at physiological densities (up to ∼10

Indexed as

Biocompatible MaterialsBioprintingTissue EngineeringAnimalsHumansHydrogelsMiceTissue ScaffoldsBiocompatible MaterialsHydrogels3D bioprintingcardiac tissuescardiomyocytescell-densedigital light processingliver tissuesneural cellsneural circuitsscaffold-freeskin regeneration

Identifiers

PMID41365296
PMCPMC13384749

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.