Evidence map›Paper›PMID 41364907›Full record

ArticleFEBS open bio2026

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using

Emily C Davies, Garth L Maker, Ian F Musgrave, Samantha Lodge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Emily C DaviesCentre for Computational and Systems Medicine, Murdoch University, Perth, Australia.ORCID https://orcid.org/0000-0001-9498-8395
Garth L MakerCentre for Computational and Systems Medicine, Murdoch University, Perth, Australia.
Ian F MusgraveAdelaide Medical School, The University of Adelaide, Australia.ORCID https://orcid.org/0000-0003-1016-0588
Samantha LodgeCentre for Computational and Systems Medicine, Murdoch University, Perth, Australia.ORCID https://orcid.org/0000-0001-9193-0462

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herbal and dietary supplements (HDS) are popular among consumers seeking a 'natural' approach for improving their health; however, at present, there is a lack of evidence to support the claims of efficacy and safety for most of these products. Herbal weight loss supplements (WLS) are a group of HDS that are frequently implicated in cases of toxicity; however, the causative substances often remain unknown due to the complex chemical nature of such supplements. This study aimed to analyse the in vitro safety (in human liver carcinoma (HepG2) cells and colon carcinoma (Caco-2) cells) of 12 active compounds commonly found in WLS, first with safety screening using the MTT cytotoxicity assay, followed by metabolic profiling with

Indexed as

Dietary SupplementsPhytochemicalsWeight LossCaco-2 CellsCatechinCell SurvivalHep G2 CellsHumansProton Magnetic Resonance SpectroscopyCatechinepigallocatechin gallatePhytochemicals1H NMR spectroscopyCaco‐2 cellsepigallocatechin‐3,0‐gallateHepG2 cellsherbal weight loss supplementsoxidative stress

Identifiers

PMID41364907
PMCPMC13145343

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.