Evidence map›Paper›PMID 41364542›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2026

Intestinal adaptations increase basolateral intestinal glucose uptake and glycolysis in a mouse model of cystic fibrosis.

Alexander F Lesser, Aura Perez, Chunying Wu, Shuyu Hao, Bernadette Erokwu, Derek Host, Anjum Jafri, Elisha Barbato, Lauren Yeh, Jean Eastman and 3 more

Abstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alexander F LesserDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, United States.ORCID 0000-0003-4199-7946
Aura PerezDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, United States.ORCID 0009-0009-6140-1194
Chunying WuDepartment of Radiology, Case Western Reserve University, Cleveland, Ohio, United States.
Shuyu HaoDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, United States.
Bernadette ErokwuDepartment of Radiology, Case Western Reserve University, Cleveland, Ohio, United States.
Derek HostDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, United States.ORCID 0000-0001-6921-5382
Anjum JafriDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, United States.
Elisha BarbatoDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, United States.
Lauren YehDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, United States.ORCID 0000-0002-7845-3451
Jean EastmanDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, United States.
Senthilkumar SankararamanDepartment of Pediatric Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, Ohio, United States.
Chris A FlaskDepartment of Radiology, Case Western Reserve University, Cleveland, Ohio, United States.ORCID 0000-0002-1066-333X
Mitchell L DrummDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, United States.ORCID 0000-0003-4739-5153

Funding

Medical Scientist Training Program at Case Western Reserve UniversityT32GM152319 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI Heather Broihier, Alex Yee-Chen Huang · 2024 to 2026
$5.1M
Animal Model Resources for Cystic FibrosisR24RR032425 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DRUMM, MITCHELL L, HODGES, CRAIG A · 2011 to 2011
$560k
Cystic Fibrosis Foundation (CFF) DRUMM22G0-GICystic Fibrosis Foundation (CFF) DRUMM24R0HHS | NIH | NIH Office of the Director (OD) S10OD03049901NCRR NIH HHS R24 RR032425NIGMS NIH HHS T32 GM152319
6 · The paper itself

Abstract

The gastrointestinal manifestations of cystic fibrosis (CF) are a continued source of morbidity and mechanistic uncertainty despite recent advances in CF care. We sought to characterize intestinal glucose demand in a mouse model of CF to better understand CF intestinal disease. We assessed in vivo systemic glucose uptake from circulation, including intestinal glucose demand, using

Indexed as

Cystic FibrosisGlucoseGlycolysisIleumIntestinal MucosaJejunumAdaptation, PhysiologicalAnimalsDisease Models, AnimalFluorodeoxyglucose F18Glucose Transporter Type 1MaleMiceMice, Inbred C57BLFluorodeoxyglucose F18GlucoseGlucose Transporter Type 1Slc2a1 protein, mousecystic fibrosisglucose metabolismglucose uptakeintestinemouse

Identifiers

PMID41364542
PMCPMC12857195

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.