Evidence map›Paper›PMID 41364337›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026

Evolving our understanding of vitamin D, periostin levels and cardiovascular risk in the elderly: a cross sectional study.

Maria Luisa Brandi, Francesca Marini, Simone Parri, Stefania Bandinelli, Teresa Iantomasi, Francesca Giusti, Eleonora Talluri, Giovanna Sini, Fabrizio Nannipieri, Santina Battaglia and 3 more

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maria Luisa BrandiFondazione FIRMO Onlus (Fondazione Italiana Ricerca Sulle Malattie Dell'Osso), Via San Gallo, 123-50129, Florence, Italy. marialuisa@marialuisabrandi.it.
Francesca MariniFondazione FIRMO Onlus (Fondazione Italiana Ricerca Sulle Malattie Dell'Osso), Via San Gallo, 123-50129, Florence, Italy.
Simone ParriFondazione FIRMO Onlus (Fondazione Italiana Ricerca Sulle Malattie Dell'Osso), Via San Gallo, 123-50129, Florence, Italy.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Toscana Centro, Florence, Italy.
Teresa IantomasiDonatello Bone Clinic, Villa Donatello Private Hospital , Florence, Italy.
Francesca GiustiDonatello Bone Clinic, Villa Donatello Private Hospital , Florence, Italy.
Eleonora TalluriDonatello Bone Clinic, Villa Donatello Private Hospital , Florence, Italy.
Giovanna SiniDonatello Bone Clinic, Villa Donatello Private Hospital , Florence, Italy.
Fabrizio NannipieriMedical Research, Abiogen Pharma, Pisa, Italy.
Santina BattagliaMedical Research, Abiogen Pharma, Pisa, Italy.
Giovanni TripepiNational Research Council (CNR), Ospedali Riuniti, Reggio Calabria, Italy.
Colin Gerard EganCE Medical Writing SRLS, Pisa, Italy.ORCID http://orcid.org/0000-0002-6942-7147
Luigi FerrucciLongitudinal Study Section, Translation Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.

Funding

HISPANIC SECONDARY STROKE PREVENTION INITIATIVER01MD009164 · NIMHD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN · 2014 to 2018
$1.9M
Agency for Regional Health Care of Tuscany 26/10/2012Agency for Regional Health Care of Tuscany Reg. n° 586/RMinistero della Salute ICS110.1/RF97.71NIA NIH HHS 263 MD 821336NIA NIH HHS Contracts: 263 MD 9164NIMHD NIH HHS R01 MD009164
6 · The paper itself

Abstract

This cross-sectional study explored how vitamin D and the protein periostin are related to the risk of heart disease in elderly individuals. Lower levels of both were linked to higher risk of heart disease. The findings suggest these markers may help identify cardiovascular (CV) risk as people age. PURPOSE: Given that both vitamin D and periostin are implicated in CV health, understanding their interrelationship could provide insights into the mechanisms influencing CV risk in aging populations.

methodsThis was a cross-sectional analysis in a subgroup of elderly people from the InCHIANTI Biobank in Italy. Serum concentrations of 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)

resultsSerum levels of 25(OH)D), 1,25(OH)

conclusionThis analysis identified a significant association between periostin and serum vitamin D levels, both linked to increased CV risk in the elderly, suggesting their potential role in CV disease.

Indexed as

Cardiovascular DiseasesCell Adhesion MoleculesVitamin DAgedAged, 80 and overBiomarkersCross-Sectional StudiesFemaleHeart Disease Risk FactorsHumansMaleMiddle AgedPeriostinRisk Assessment1,25-dihydroxyvitamin D25-hydroxyvitamin DBiomarkersCell Adhesion MoleculesPeriostinPOSTN protein, humanVitamin D1,25(OH)2D25(OH)DCardiovascular riskElderly peoplePeriostinVitamin D

Identifiers

PMID41364337
PMCPMC12847130

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.