Evidence map›Paper›PMID 41364309›Full record

ArticleCVIR endovascular2025

Transhepatic access closure for islet cell transplant in anticoagulated patients: a comparison of microfibrillar collagen paste, coils, and coil plus gel foam.

Qian Yu, Patrick Tran, Ethan Ungchusri, Kunal Karani, Abdul Khan, Mikin Patel, Osman Ahmed, Thuong Van Ha, Jonathan Lorenz, Steven Zangan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CVIR endovascular, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qian YuDepartment of Radiology, Vascular and Interventional Radiology, University of Chicago Medical Center, University of Chicago, Chicago, IL, 60637, USA. yuqian1006@gmail.com.ORCID http://orcid.org/0000-0001-9774-9226
Patrick TranDepartment of Radiology, Vascular and Interventional Radiology, University of Chicago Medical Center, University of Chicago, Chicago, IL, 60637, USA.
Ethan UngchusriDepartment of Radiology, Vascular and Interventional Radiology, University of Chicago Medical Center, University of Chicago, Chicago, IL, 60637, USA.
Kunal KaraniDepartment of Radiology, Vascular and Interventional Radiology, University of Chicago Medical Center, University of Chicago, Chicago, IL, 60637, USA.
Abdul KhanDepartment of Radiology, Vascular and Interventional Radiology, University of Chicago Medical Center, University of Chicago, Chicago, IL, 60637, USA.
Mikin PatelDepartment of Radiology, Vascular and Interventional Radiology, University of Chicago Medical Center, University of Chicago, Chicago, IL, 60637, USA.
Osman AhmedDepartment of Radiology, Vascular and Interventional Radiology, University of Chicago Medical Center, University of Chicago, Chicago, IL, 60637, USA.
Thuong Van HaDepartment of Radiology, Vascular and Interventional Radiology, University of Chicago Medical Center, University of Chicago, Chicago, IL, 60637, USA.
Jonathan LorenzDepartment of Radiology, Vascular and Interventional Radiology, University of Chicago Medical Center, University of Chicago, Chicago, IL, 60637, USA.
Steven ZanganDepartment of Radiology, Vascular and Interventional Radiology, University of Chicago Medical Center, University of Chicago, Chicago, IL, 60637, USA.
Brian FunakiDepartment of Radiology, Vascular and Interventional Radiology, University of Chicago Medical Center, University of Chicago, Chicago, IL, 60637, USA.
Rakesh NavuluriDepartment of Radiology, Vascular and Interventional Radiology, University of Chicago Medical Center, University of Chicago, Chicago, IL, 60637, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the safety and effectiveness of microfibrillar collagen paste (MCP), coils, and coils combined with gelatin sponge for transhepatic access tract embolization following portal vein islet cell transplant.

methodsA retrospective review was conducted at a single institution between January 2008 and October 2024, including 20, 28, and 21 consecutive islet cell transplant procedures requiring transhepatic access embolization with MCP, coils, and coil plus gelatin sponge, respectively. All procedures were performed via a right portal vein branch. MCP was performed using Avitene (BD). The average number of coils required in the coil plus gelatin sponge and coil-only groups were 1.8 and 1.6 coils per procedure, respectively. All patients were placed on therapeutic anticoagulation during the procedure and for at least two weeks post-transplant. Medical records were reviewed to compare laboratory results, portal venous pressures, post-procedure liver ultrasounds, and 30-day hemorrhagic events across the three groups.

resultsAll procedures were technically successful. However, one instance of coil migration into a portal vein branch occurred in the coil plus gelatin sponge group (1/28, 3.5%). Baseline hemoglobin, platelet counts, and partial thromboplastin time did not differ significantly between groups (p > 0.05). A statistically significant lower international normalized ratio (INR) was observed in the MCP group compared to the gelatin sponge and coil-only groups (1.0 vs. 1.1 vs. 1.1, p = 0.0036 and 0.004). No statistically significant differences were found in hemoglobin changes, post-transplant portal venous pressures, or post-embolization hemorrhagic events (p > 0.05). One patient in the coil plus gelatin sponge group developed a large subcapsular hematoma (1/27, 3.7%), while another in the MCP group experienced a large right hemothorax (1/20, 5.0%).

conclusionMCP, coils, and coil plus gelatin sponge are similarly effective for transhepatic access closure following islet cell transplant in anticoagulated patients. However, coil embolization may require multiple coils and carries a risk of migration.

Indexed as

EmbolizationIslet cell transplantPortal veinTranshepatic access

Identifiers

PMID41364309
PMCPMC12690018

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.