Impact of extended duration pharmacological thromboprophylaxis on venous thromboembolism after hip and knee arthroplasty and hip fracture surgery: a systematic review and meta-analysis of randomised controlled trials.

Usha Gurunathan, Matthew Bright, Daniel Mullany, Mathew Judd, Karen Hay, Harshal Nandurkar, Victoria Eley

Abstract readSystematic ReviewMeta-Analysis

In one paragraph

Synthesis in Journal of thrombosis and thrombolysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Usha GurunathanDepartment of Anaesthesia and Perfusion Services, The Prince Charles Hospital, Brisbane, 4032, Australia. u.gurunathan@uq.edu.au.ORCID http://orcid.org/0000-0002-0336-872X

Matthew BrightDepartment of Anaesthesia and Perfusion Services, The Prince Charles Hospital, Brisbane, 4032, Australia.

Daniel MullanyDepartment of Anaesthesia and Perfusion Services, The Prince Charles Hospital, Brisbane, 4032, Australia.

Mathew JuddFaculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, 4006, Australia.

Karen HayStatistics Unit, QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia.

Harshal NandurkarDepartment of Clinical Haematology, Alfred Hospital, and Australian Centre for Blood Diseases, Monash University, Melbourne, 3004, VIC, Australia.

Victoria EleyFaculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, 4006, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical practice guidelines on the optimal thromboprophylaxis duration following total hip and knee arthroplasty (THA and TKA) and hip fracture surgery are inconsistent. The aim of this meta-analysis is to investigate the effect of pharmacological prophylaxis duration on postoperative venous thromboembolism (VTE) in these patients. The primary outcome was the incidence of symptomatic and confirmed VTE at three months following surgery. A systematic search was performed in MEDLINE Complete (EBSCO), Embase, CINAHL complete (EBSCO), Web of Science and in CENTRAL databases, for randomised controlled trials comparing extended (minimum 28 days for THA and 10 days for TKA) vs. shorter duration thromboprophylaxis or placebo following these operations. Fifteen trials with a total of 26,580 participants were identified. Compared to shorter prophylaxis, extended thromboprophylaxis reduced 90-day symptomatic and confirmed VTE (OR: 0.43; 95% CI: 0.26-0.72; P = 0.001, I

Indexed as

Arthroplasty, Replacement, HipArthroplasty, Replacement, KneeHip FracturesPostoperative ComplicationsVenous ThromboembolismHumansRandomized Controlled Trials as TopicAnticoagulantsArthroplastyHip fracturesVenous thromboembolismVenous thrombosis

Identifiers

PMID41364287

DOI10.1007/s11239-025-03211-1

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.