Evidence map›Paper›PMID 41364260›Full record

ArticleVeterinary research communications2025

Amyloid A amyloidosis associated with Streptococcus suis infection in a young commercial pig with wild-type serum amyloid A.

Susumu Iwaide, Hayate Nishiura, Natsumi Kobayashi, Tomoaki Murakami, Yoshiyuki Itoh, Kumiko Kimura, Ayako Okada, Yuko Tsuka, Shoya Takaki, Tomoyuki Shibahara

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In one paragraph

Article in Veterinary research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Susumu IwaideNational Institute of Animal Health, National Agriculture and Food Research Organization, 3-1-5 Kannondai, Tsukuba, Ibaraki, Japan. fq3733@go.tuat.ac.jp.
Hayate NishiuraNational Institute of Animal Health, National Agriculture and Food Research Organization, 3-1-5 Kannondai, Tsukuba, Ibaraki, Japan.
Natsumi KobayashiLaboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo, Japan.
Tomoaki MurakamiLaboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo, Japan.
Yoshiyuki ItohSmart-Core-Facility Promotion Organization, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo, Japan.
Kumiko KimuraNational Institute of Animal Health, National Agriculture and Food Research Organization, 3-1-5 Kannondai, Tsukuba, Ibaraki, Japan.
Ayako OkadaTottori Prefectural Kurayoshi Livestock Hygiene Service Center, 2-132 Seidani-cho, Tottori, Tottori, Japan.
Yuko TsukaTottori Prefectural Kurayoshi Livestock Hygiene Service Center, 2-132 Seidani-cho, Tottori, Tottori, Japan.
Shoya TakakiTottori Prefectural Kurayoshi Livestock Hygiene Service Center, 2-132 Seidani-cho, Tottori, Tottori, Japan.
Tomoyuki ShibaharaNational Institute of Animal Health, National Agriculture and Food Research Organization, 3-1-5 Kannondai, Tsukuba, Ibaraki, Japan.

Funding

Japan Society for the Promotion of Science 23H02380
6 · The paper itself

Abstract

Amyloid A (AA) amyloidosis is a progressive disease caused by the deposition of AA, an abnormally folded protein derived from serum amyloid A (SAA), in organs throughout the body. AA amyloidosis occurs in various mammals and birds but is extremely rare in commercial pigs. A possible reason for this is that a variant SAA is crucial for the onset of AA amyloidosis in pigs. However, AA amyloidosis with wild-type SAA was recently reported in microminipigs, which are the smallest laboratory pigs, leaving the importance of this variant unclear. This is a report of the involvement of wild-type SAA in AA amyloidosis in 4-month-old three-way crossed pigs (Landrace, Large White, and Duroc: LWD). Using immunohistochemistry, transmission electron microscopy, mass spectrometry, and DNA sequencing, we determined that the amyloid fibrils were derived from wild-type SAA without detectable variant, which is a rare finding in commercial pigs. This finding suggests that AA amyloidosis can occur in commercial pigs regardless of the presence of the SAA variant.

Indexed as

AmyloidosisSerum Amyloid A ProteinStreptococcal InfectionsStreptococcus suisSwine DiseasesAnimalsSwineSerum Amyloid A ProteinAmyloid A amyloidosisMass spectrometrySpleenStreptococcus suisSwine

Identifiers

PMID41364260

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.