Evidence map›Paper›PMID 41364249›Full record

ArticleNeurosurgical review2025

Cohort analysis of surgically managed Chiari malformation type 1: real-world data from multi-centres.

Fang Wang, Mingkun Wei, Dingkang Xu, Zikuo Wang, Jichao Yang, Yongli Lou, Lei Hui, Shuangzhu Yue, Yongsheng Liu, Zhen Yang and 39 more

Abstract readMulticenter Study
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Article in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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49 authors.

Fang Wang *Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, Henan Province, 450001, China.ORCID http://orcid.org/0000-0002-1474-2297
Mingkun Wei *Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, Henan Province, 450001, China.
Dingkang Xu *Department of Neurosurgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.ORCID http://orcid.org/0000-0002-9153-773X
Zikuo WangDepartment of Neurosurgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, No. 7, Weiwu Road, Zhengzhou, Henan, 450003, China.
Jichao YangDepartment of Neurospine Surgery, Zhengzhou Central Hospital, Zhengzhou University, North Tongbai Road, Zhengzhou, Henan Province, 450007, China.
Yongli LouDepartment of Neurospine Surgery, Zhengzhou Central Hospital, Zhengzhou University, North Tongbai Road, Zhengzhou, Henan Province, 450007, China.
Lei HuiDepartment of Neurosurgery, The First Affiliated Hospital of Henan Medical University, No. 88, Jiankang Road, Weihui, Henan Province, 453100, China.
Shuangzhu YueDepartment of Neurosurgery, The First Affiliated Hospital of Henan Medical University, No. 88, Jiankang Road, Weihui, Henan Province, 453100, China.
Yongsheng LiuDepartment of Neurosurgery, The First People's Hospital of Shangqiu City, No. 292, Kaixuan South Road, Shangqiu, Henan Province, 476000, China.
Zhen YangDepartment of Neurosurgery, The First People's Hospital of Shangqiu City, No. 292, Kaixuan South Road, Shangqiu, Henan Province, 476000, China.
Yuanfeng ZhangDepartment of Neurosurgery, Nanyang Center Hospital, No. 312, Gongnong Road, Nanyang, Wancheng District, Henan Province, 473000, China.
Yitong WeiDepartment of Neurosurgery, Nanyang Center Hospital, No. 312, Gongnong Road, Nanyang, Wancheng District, Henan Province, 473000, China.
Yansheng GaoDepartment of Neurosurgery, Zhumadian Central Hospital, NO. 747, Zhonghua Avenue, Zhumadian, Henan province, 463000, China.
Qinglin WangDepartment of Neurosurgery, Zhumadian Central Hospital, NO. 747, Zhonghua Avenue, Zhumadian, Henan province, 463000, China.
Shengqi ZhaoDepartment of Neurosurgery, Zhumadian Central Hospital, NO. 747, Zhonghua Avenue, Zhumadian, Henan province, 463000, China.
Xiaolong GuoDepartment of Neurosurgery, The First Affiliated Hospital of Henan University of Science and Technology University, No. 636, Guanlin Road, Luoyang, Luolong District, Henan Province, 471000, China.
Jinsong WuDepartment of Neurosurgery, The First Affiliated Hospital of Henan University of Science and Technology University, No. 636, Guanlin Road, Luoyang, Luolong District, Henan Province, 471000, China.
Qingjie WeiDepartment of Neurosurgery, The First Affiliated Hospital of Henan University of Science and Technology University, No. 636, Guanlin Road, Luoyang, Luolong District, Henan Province, 471000, China.
Yanpeng JianDepartment of Spine Surgery, Xuchang Central Hospital, No. 30, Huatuo Road, Xuchang City, Weidu District, Henan Province, 461000, China.
Kangqi JiDepartment of Spine Surgery, Xuchang Central Hospital, No. 30, Huatuo Road, Xuchang City, Weidu District, Henan Province, 461000, China.
Qiao ShanDepartment of Neurosurgery, The Third Affiliated Hospital of Zhengzhou University, No. 7, Kangfuqian Street, Zhengzhou, Erqi, Henan Province, 450052, China.
Jinyu LiuDepartment of Neurosurgery, The Third Affiliated Hospital of Zhengzhou University, No. 7, Kangfuqian Street, Zhengzhou, Erqi, Henan Province, 450052, China.
Li JianDepartment of Neurosurgery, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, No. 19, Renmin Road, Zhengzhou, Henan Province, 450000, China.
Haojun YouDepartment of Neurosurgery, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, No. 19, Renmin Road, Zhengzhou, Henan Province, 450000, China.
Qinghe YaoDepartment of Neurosurgery, Luoyang Central Hospital, No. 288, Zhongzhou Road, Luoyang, Henan Province, 471000, China.
Jiali YaoDepartment of Neurosurgery, Luoyang Central Hospital, No. 288, Zhongzhou Road, Luoyang, Henan Province, 471000, China.
Shubin FengDepartment of Neurosurgery, Children's Hospital Affiliated to Zhengzhou University, No. 33, East Longhu Outer Ring Road, Zhengzhou, 450001, Henan Province, China.
Qiang FengDepartment of Neurosurgery, Children's Hospital Affiliated to Zhengzhou University, No. 33, East Longhu Outer Ring Road, Zhengzhou, 450001, Henan Province, China.
Dandong FangDepartment of Neurosurgery, Sanmenxia Central Hospital, Sanmenxia, Henan Province, 472000, China.
Yuan AnDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, Henan Province, 450001, China.ORCID http://orcid.org/0000-0002-6347-7653
Yan DuDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, Henan Province, 450001, China.
Mingchu ZhangDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, Henan Province, 450001, China.
Kaiyuan ZhangDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, Henan Province, 450001, China.ORCID http://orcid.org/0009-0008-5934-1236
Junhao FangDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, Henan Province, 450001, China.
Mengzhao FengDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, Henan Province, 450001, China.ORCID http://orcid.org/0000-0002-0933-1899
Mengyuan LiDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, Henan Province, 450001, China.
Dengpan SongDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, Henan Province, 450001, China.ORCID http://orcid.org/0000-0001-5240-7601
Bangqing WangDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, Henan Province, 450001, China.
Kai YinDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, Henan Province, 450001, China.
Yan HuDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, Henan Province, 450001, China.
Yuchao ZuoDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, Henan Province, 450001, China.
Bin YuDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, Henan Province, 450001, China.
Weiguang WangDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, Henan Province, 450001, China.
Ruixia YuanDepartment of Clinical Big Data Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450001, China.
Ali Çağlar TurgutInternational Joint Laboratory of Nervous System Malformations of Henan Province, Zhengzhou, Henan, 450001, China.
Cenk EraslanInternational Joint Laboratory of Nervous System Malformations of Henan Province, Zhengzhou, Henan, 450001, China.
Jun ZhangDepartment of Molecular & Translational Medicine (MTM), Texas Tech University Health Science Center El Paso (TTUHSCEP), El Paso, TX, 79905, USA.
Jorge A LazareffDavid Geffen School of Medicine, University of California Los Angeles, UCLA, Los Angeles, CA, USA.
Fuyou GuoDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, Henan Province, 450001, China. chyou666@hotmail.com.ORCID http://orcid.org/0000-0001-9332-8272

Funding

Henan Province science and technology research project 232102310127Key project of international science and technology cooperation, Science and Technology Department of Henan Province 241111520600Key scientific and technological projects in Henan Province 242102311220National Natural Science Foundation of China 82503692Project of Clinical Research for Doctor of Henan Province HNCRD202424
6 · The paper itself

Abstract

The uniform and optimal management of Chiari malformation type 1 (CM1) has not yet been established. The study aimed to investigate the clinical characteristics and surgical outcomes of patients with CM1 in China. Data from 827 patients who underwent various surgical procedures for CM1 across 14 centres in China were analysed. Clinical characteristics were evaluated, and the inverse probability of treatment weights methods was applied to estimate the relationships between risk factors and functional outcomes. Syringomyelia was observed in most cases (754; 91.17%) in this cohort. A positive correlation was found between disease duration and age at diagnosis (P = 0.0002). Conversely, disease duration showed a significant negative correlation with preoperative Japanese Orthopaedic Association (JOA) score (P < 0.0001), postoperative JOA score (P < 0.0001), and Chicago Chiari Outcome Scale score. Patients who underwent posterior fossa decompression with tonsil resection/cautery (PFDRT) surgery had the highest mean postoperative JOA score (15.51 ± 1.84) compared with those in the posterior fossa decompression (PFD), posterior fossa decompression with duraplasty, and other groups (P = 0.0297). Postoperative complications were more frequent after PFDRT than after PFD (P = 0.0443). However, the reoperation rate of PFDRT was significantly lower than that for PFD (P = 0.0057). Surgeries providing adequate cerebrospinal fluid decompression yielded superior outcomes compared with simple bony decompression or cerebrospinal fluid shunting. Age at diagnosis, craniocervical malformation, disease duration, and surgical approach are key factors influencing CM1 outcomes. Chinese Clinical Trial Registry, Number: ChiCTR2400080007, Registered on January 18th, 2024.

Indexed as

Arnold-Chiari MalformationDecompression, SurgicalNeurosurgical ProceduresAdolescentAdultAgedChildChild, PreschoolChinaCohort StudiesFemaleHumansMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesChiari malformationClinical studyMulticentreReal-worldSyringomyelia

Identifiers

PMID41364249

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