Evidence map›Paper›PMID 41364236›Full record

ArticleHistochemistry and cell biology2025

Phenotypic and ultrastructural heterogeneity of fibroblasts and vasculogenic mimicry in rectal adenocarcinoma following neoadjuvant chemoradiotherapy.

Nataliya Bgatova, Nikita Skudin, Anastasia Shatruk, Iuliia Taskaeva, Natalya Obanina, Maksim Ryaguzov, Aleksey Lomakin, Mikhail Karpov, Sergey Fursov

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Article in Histochemistry and cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nataliya BgatovaResearch Institute of Clinical and Experimental Lymphology-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia.
Nikita SkudinNovosibirsk Regional Clinical Oncology Dispensary, Novosibirsk, Russia.
Anastasia ShatrukResearch Institute of Clinical and Experimental Lymphology-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia.
Iuliia TaskaevaResearch Institute of Clinical and Experimental Lymphology-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia. taskaeva.iuliia@gmail.com.
Natalya ObaninaResearch Institute of Clinical and Experimental Lymphology-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia.
Maksim Ryaguzov"EUROMED" Clinic, Novosibirsk, Russia.
Aleksey LomakinNovosibirsk Regional Clinical Oncology Dispensary, Novosibirsk, Russia.
Mikhail KarpovResearch Institute of Clinical and Experimental Lymphology-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia.
Sergey FursovNovosibirsk Regional Clinical Oncology Dispensary, Novosibirsk, Russia.

Funding

Russian Academy of Sciences FWNR-2025-0015
6 · The paper itself

Abstract

Neoadjuvant chemoradiotherapy (nCRT) followed by surgery is the standard treatment for locally advanced rectal cancer. However, the response to nCRT is variable and not always associated with improved survival. Colorectal cancer (CRC) is characterized by a complex tumor microenvironment (TME), a key component of which is cancer-associated fibroblasts (CAF). While their functions and interactions with tumor cells are under active investigation, the role of distinct CAF subpopulations and their plasticity remains largely undefined. A comprehensive characterization of CAFs during cancer progression could therefore contribute to the development of novel anticancer diagnostic and therapeutic strategies. In this study, we used immunohistochemistry to demonstrate that nCRT induces a significant reorganization of the TME in rectal adenocarcinoma. This reorganization was characterized by a redistribution of myofibroblasts (alpha-smooth muscle actin, αSMA

Indexed as

AdenocarcinomaChemoradiotherapyFibroblastsNeoadjuvant TherapyNeovascularization, PathologicRectal NeoplasmsAgedCancer-Associated FibroblastsFemaleHumansMaleMiddle AgedPhenotypeTumor MicroenvironmentCancer-associated fibroblastsImmunohistochemistryNeoadjuvant chemoradiotherapyRectal adenocarcinomaUltrastructureVasculogenic mimicry

Identifiers

PMID41364236

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.