Evidence map›Paper›PMID 41364222›Full record

ArticleAbdominal radiology (New York)2026

Pancreatic solid pseudopapillary neoplasms in male patients exhibit different clinical and imaging features compared with those in female patients.

Ryohei Kozuki, Keitaro Sofue, Takamichi Murakami, Akiyoshi Suzuki, Akira Katayama, Hisataka Ito, Eriko Yoshizawa, Kenichi Tanaka, Masashi Kusakabe, Katsuhiro Sano and 5 more

Abstract readComparative StudyMulticenter Study
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In one paragraph

Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Ryohei KozukiDepartment of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan.
Keitaro SofueDepartment of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan. keitarosofue@gmail.com.
Takamichi MurakamiDepartment of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan.
Akiyoshi SuzukiDepartment of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Akira KatayamaDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Hisataka ItoDepartment of Diagnostic Radiology, Kurashiki Central Hospital, Kurashiki, Japan.
Eriko YoshizawaDepartment of Radiology, Shinshu University School of Medicine, Matsumoto, Japan.
Kenichi TanakaDepartment of Radiology, Faculty of Medicine, Kagawa University, Miki, Japan.
Masashi KusakabeDepartment of Radiology, NTT Medical Center Tokyo, Tokyo, Japan.
Katsuhiro SanoDepartment of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Akira YamadaDepartment of Radiology, Shinshu University School of Medicine, Matsumoto, Japan.
Takayuki SanomuraDepartment of Radiology, Faculty of Medicine, Kagawa University, Miki, Japan.
Takayuki KodamaDivision of Molecular and Genomic Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan.
Takashi KoyamaDepartment of Diagnostic Radiology, Kurashiki Central Hospital, Kurashiki, Japan.
Manabu MinamiDepartment of Radiology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe purpose of this study was to investigate the clinical and imaging features of solid pseudopapillary neoplasms (SPNs) in men and to compare with those in women.

methodsOne hundred twenty-two patients (38 men and 84 women) with histologically confirmed SPNs from seven institutions were retrospectively analyzed. Clinical data, including demographics and preoperative diagnoses, were reviewed, and imaging characteristics on computed tomography, magnetic resonance imaging, and

resultsMen were significantly older than women (mean age: 43.7 years vs. 31.1 years, p < 0.001) and had smaller tumors (mean size: 28.5 mm vs. 38.5 mm, p = 0.014). Regarding preoperative diagnosis, SPN was suspected less frequently in men (p < 0.001), with a higher rate of biopsy (p = 0.006). Imaging characteristics revealed that SPNs in men had fewer hemorrhagic changes (p = 0.035), more frequent internal calcifications (p = 0.003), and a higher proportion of solid components (p = 0.009). In women, tumor size (ρ = - 0.292, p = 0.007) and the proportion of solid components (ρ = - 0.276, p = 0.011) negatively correlated with age, whereas no correlations were observed in men.

conclusionSPNs in men exhibit distinct clinical and imaging characteristics, including older age, smaller size, a greater proportion of solid components, and fewer degenerative features compared with those in women. Recognizing these sex-specific differences is important for improving diagnostic accuracy and guiding the optimal management of patients with SPNs.

Indexed as

Carcinoma, PapillaryPancreatic NeoplasmsTomography, X-Ray ComputedAdultAgedFemaleFluorodeoxyglucose F18HumansMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographyRadiopharmaceuticalsRetrospective StudiesSex FactorsFluorodeoxyglucose F18RadiopharmaceuticalsComputed tomographyMagnetic resonance imagingPancreasSexSolid pseudopapillary neoplasm

Identifiers

PMID41364222

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