Evidence map›Paper›PMID 41364195›Full record

ReviewRadiologie (Heidelberg, Germany)2026

[Pseudoprogression after start of immunotherapy].

Michael Winkelmann, Matthias Kassube, Philipp Linden, Johannes Rübenthaler, Gabriel T Sheikh, Wolfgang G Kunz

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Radiologie (Heidelberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael WinkelmannKlinik und Poliklinik für Radiologie, LMU Klinikum, München, Marchioninistr. 15, 81377, München, Deutschland.
Matthias KassubeKlinik und Poliklinik für Radiologie, LMU Klinikum, München, Marchioninistr. 15, 81377, München, Deutschland.
Philipp LindenKlinik und Poliklinik für Radiologie, LMU Klinikum, München, Marchioninistr. 15, 81377, München, Deutschland.
Johannes RübenthalerKlinik und Poliklinik für Radiologie, LMU Klinikum, München, Marchioninistr. 15, 81377, München, Deutschland.
Gabriel T SheikhKlinik und Poliklinik für Nuklearmedizin, LMU Klinikum, München, Deutschland.
Wolfgang G KunzKlinik und Poliklinik für Radiologie, LMU Klinikum, München, Marchioninistr. 15, 81377, München, Deutschland. wolfgang.kunz@med.lmu.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

clinical/methodical issueDistinguishing pseudoprogression from true progression represents a considerable challenge in both clinical practice and radiological imaging. STANDARD RADIOLOGICAL

methodsEstablished radiological methods include computed tomography (CT) and magnetic resonance imaging (MRI), complemented by fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT from nuclear medicine. METHODICAL INNOVATIONS: Novel PET/CT tracers, liquid biopsies, and radiomics are considered innovative approaches that may facilitate the detection of pseudoprogression but still need clinical validation. PERFORMANCE: CT, MRI, and PET/CT can provide valuable clues for distinguishing pseudoprogression from true progression, but are often inconclusive. Novel imaging approaches are currently under investigation in clinical studies. ACHIEVEMENTS: The use of laboratory markers and radiomics has shown promising improvements in several studies, but has not yet been adopted into clinical routine. PRACTICAL RECOMMENDATIONS: In clinically stable patients, suspected pseudoprogression early after start of immunotherapy justifies continuation of therapy with close imaging follow-up (early follow-up after 4-8 weeks).

Indexed as

ImmunotherapyNeoplasmsDisease ProgressionHumansMagnetic Resonance ImagingPositron Emission Tomography Computed TomographyTomography, X-Ray ComputedCheckpoint inhibitorsChimeric antigen receptorLiquid biopsyResponse Evaluation Criteria in Solid TumoursTumour markers

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.