Evidence map›Paper›PMID 41364194›Full record

ReviewArchives of microbiology2025

The dual implications of iron homeostasis as a bacterial threat: its roles in virulence and antimicrobial resistance.

Naveenraj Rajasekar, Vijaya Bharathi Srinivasan, Karthikeyan Krishnan, Chankit Giri, Mahesh Kumar, Balvinder Singh, Govindan Rajamohan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Naveenraj RajasekarCSIR-Institute of Microbial Technology, Sector 39A, Chandigarh, India.
Vijaya Bharathi SrinivasanCSIR-Institute of Microbial Technology, Sector 39A, Chandigarh, India.
Karthikeyan KrishnanCSIR-Institute of Microbial Technology, Sector 39A, Chandigarh, India.
Chankit GiriCSIR-Institute of Microbial Technology, Sector 39A, Chandigarh, India.
Mahesh KumarCSIR-Institute of Microbial Technology, Sector 39A, Chandigarh, India.
Balvinder SinghCSIR-Institute of Microbial Technology, Sector 39A, Chandigarh, India.
Govindan RajamohanCSIR-Institute of Microbial Technology, Sector 39A, Chandigarh, India. rmohan@imtech.res.in.

Funding

Council of Scientific and Industrial Research, India MLP0039, MLP045, OLP189Indian Council of Medical Research 2020-3673; 5403-2023
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) is a global health concern that requires innovative therapeutic strategies to improve clinical outcomes. Bacterial priority pathogens have developed multiple mechanisms for AMR. To develop therapeutics to overcome AMR, it is essential to explore, understand, and identify effective molecular targets. Iron is crucial for survival and pathogenesis in bacterial physiology. Reports indicate that iron supports vital cellular functions and modulates bacterial virulence and pathogenicity. Due to the bacterial requirement for iron during infection, antimicrobials are being developed by targeting iron homeostasis pathways in pathogens. In this review, we explore the virulence, AMR, and iron homeostatic mechanisms in bacterial pathogens, as well as the functional role of iron in regulating virulence, antimicrobial resistance, and other aspects of bacterial physiology, to elucidate potential therapeutic strategies against drug-resistant pathogens. This review briefly discusses therapeutic interventions based on iron homeostasis mechanisms and the associated translational challenges.

Indexed as

BacteriaDrug Resistance, BacterialHomeostasisIronAnimalsAnti-Bacterial AgentsBacterial InfectionsHumansVirulenceAnti-Bacterial AgentsIronAntimicrobial resistanceCritical pathogenIron regulationVirulence

Identifiers

PMID41364194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.