Evidence map›Paper›PMID 41364151›Full record

ArticleAging clinical and experimental research2025

Osteocalcin and frailty among older women.

Tine Kolenda Paulin, Linnea Malmgren, Patrik Bartosch, Kaisa K Ivaska, Fiona E A McGuigan, Kristina E Akesson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tine Kolenda PaulinClinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden. tine.kolendapaulin@skane.se.ORCID http://orcid.org/0000-0002-7248-2534
Linnea MalmgrenClinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0003-3296-7083
Patrik BartoschClinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0002-7562-4067
Kaisa K IvaskaInstitute of Biomedicine, University of Turku, Turku, 20520, Finland.ORCID http://orcid.org/0000-0001-7482-7623
Fiona E A McGuiganClinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0002-8033-9981
Kristina E AkessonClinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0003-3024-2804

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOsteocalcin is a bone-specific protein involving many physiological processes, primarily bone turnover. Also closely related to the musculoskeletal system is the frailty syndrome.

aimTo investigate if circulating osteocalcin levels and frailty are associated in the old, and in addition, if the presumed association is mediated through alterations in bone.

methods999 community-dwelling women from the OPRA (Osteoporosis Prospective Risk Assessment) cohort, all aged 75 years. Serum total osteocalcin was measured together with bone turnover markers PINP and CTX. An OPRA-adapted frailty index was applied. Association between osteocalcin and frailty was investigated using both logistic regression (osteocalcin quintiles Q

resultsLow osteocalcin (Q

conclusionLow osteocalcin in circulation was associated with being frail, also after adjusting for bone turnover markers.

Indexed as

Frail ElderlyFrailtyOsteocalcinAgedAged, 80 and overBiomarkersBone RemodelingFemaleHumansProspective StudiesBiomarkersOsteocalcinBone turnover markersFrailtyOld individualsOsteocalcin

Identifiers

PMID41364151
PMCPMC12689723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.