Evidence map›Paper›PMID 41364125›Full record

ArticleBiogerontology2025

Verbascoside from Callicarpa nudiflora Hook extends lifespan in Caenorhabditis elegans via SKN-1 pathway activation.

Yuhang Liu, Jiale Wu, Zhiyang Ding, Liru Chen, Manyu Liu, Baoli Li, Xiaokang Li, Jian Li, Wenwen Liu

Abstract read
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In one paragraph

Article in Biogerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuhang Liu *Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China.
Jiale Wu *Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China.
Zhiyang Ding *Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China.
Liru ChenKey Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China.
Manyu LiuKey Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China.
Baoli LiKey Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China.
Xiaokang LiState Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materialbiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Jian LiKey Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China. jianli@ecust.edu.cn.
Wenwen LiuKey Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China. wenwenliu@hainanu.edu.cn.

Funding

Chinese Special Fund for State Key Laboratory of Bioreactor Engineering 2060204National Natural Science Foundation of China 22037002National Natural Science Foundation of China 22207026 and 22477020the Innovative Research Team of High-level Local Universities in Shanghai SHSMU-ZDCX20212702
6 · The paper itself

Abstract

Aging involves a progressive decline in physiological function, leading to organ damage and age-related chronic diseases. Natural products derived from traditional herbs represent a valuable resource for identifying anti-aging compounds and potential lead candidates. In this study, a screen of an herbal library using Caenorhabditis elegans (C. elegans) identified the 75% ethanol extract of Callicarpa nudiflora Hook (LWLY01) as a potent lifespan-extending agent. Further fractionation revealed that its ethyl acetate extract (LWLY03) exhibited significant anti-aging activity, albeit with complex composition. Through systematic isolation and identification, verbascoside was determined to be a key active constituent. Verbascoside extended the lifespan of C. elegans and improved healthspan parameters, including motility and resistance to osmotic and thermal stress. Mutant lifespan assays demonstrated that verbascoside acts through activation of the SKN-1 signaling pathway, thereby strengthening resistance to aging-associated oxidative stress. Additionally, verbascoside was found to regulate multiple aging-related processes, such as stress response, oxidative damage, and cellular homeostasis. These findings highlight verbascoside as a promising natural compound for mitigating aging phenotypes and preventing age-related diseases.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsDNA-Binding ProteinsGlucosidesLongevityPhenolsPlant ExtractsTranscription FactorsAnimalsOxidative StressPolyphenolsSignal TransductionacteosideCaenorhabditis elegans ProteinsDNA-Binding ProteinsGlucosidesPhenolsPlant ExtractsPolyphenolsskn-1 protein, C elegansTranscription FactorsAnti-agingC. elegansHealthspanLifespanSKN-1Verbascoside

Identifiers

PMID41364125

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.