Evidence map›Paper›PMID 41364058›Full record

ArticleJACC. Case reports2026

Multidisciplinary Management of Heritable Aortopathy in Pregnancy Complicated by Postpartum Acute Type A Dissection.

Alexandra E Sperry, Aardra Rajendran, Michael Salna, Catherine Klammer, Grace J Wang, Chase R Brown, Lisa Levine, Jennifer Lewey, Nimesh D Desai

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexandra E SperryDivision of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: alexandra.sperry@pennmedicine.upenn.edu.
Aardra RajendranDivision of Cardiology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Perelman Center for Advanced Medicine, Philadelphia, Pennsylvania, USA.
Michael SalnaDepartment of Cardiothoracic Surgery, New York University, New York, New York, USA.
Catherine KlammerDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Grace J WangDivision of Vascular Surgery Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Chase R BrownDivision of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Lisa LevineDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jennifer LeweyDepartment of Cardiothoracic Surgery, New York University, New York, New York, USA.
Nimesh D DesaiDivision of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Funding

Training Program in Cardiovascular Biology and MedicineT32HL007843 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI THOMAS P. CAPPOLA, Sharlene M Day · 1996 to 2026
$11.0M
NHLBI NIH HHS T32 HL007843
6 · The paper itself

Abstract

case summaryA 33-year-old patient at 20 weeks of gestation presented with a dilated aortic root and abdominal aorta, and a diagnosis of Loeys-Dietz syndrome was made. KEY QUESTIONS: What is the incidence of pregnancy-related aortic dissection in patients with heritable thoracic aortic disease (HTAD)? What are the key management principles for pregnant patients with HTAD? OUTCOME: A shared plan was made by a multidisciplinary team of maternal fetal medicine, cardio-obstetrics, and cardiothoracic surgery, consisting of imaging surveillance, blood pressure control, scheduled cesarean delivery, and future elective aortic surgery. After an uncomplicated delivery, the patient experienced an acute type A dissection requiring staged total aortic replacement, including aortic root and arch replacement, thoracoabdominal aortic replacement, and endovascular aortic repair. TAKE-HOME MESSAGES: Patients with HTAD are at an increased risk of pregnancy-related aortic dissection. Key management principles include multidisciplinary evaluation, imaging surveillance, blood pressure control, and delivery with cardiothoracic surgical backup.

Indexed as

aortic dissectionconnective tissue diseasegenetic syndromehereditary thoracic aortic diseasepregnancy

Identifiers

PMID41364058
PMCPMC12882334

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.