Evidence map›Paper›PMID 41363845›Full record

ArticleJournal of virology2026

SVCV phosphoprotein hijacks phase separation to immobilize the IRF3-TBK1 signaling axis and suppress interferon antiviral immunity.

Yueyi Wang, Fengyun Wu, Dongdong Fan, Aifu Lin, Lixin Xiang, Ye Chen, Jianzhong Shao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Animals : an open access journal from MDPI · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yueyi WangCollege of Life Sciences, Key Laboratory of Cell and Molecular Intelligent Design and Development of Zhejiang Province, Division of Medical Genetics and Genomics, the Children's Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.ORCID 0009-0004-1463-0123
Fengyun WuCollege of Life Sciences, Key Laboratory of Cell and Molecular Intelligent Design and Development of Zhejiang Province, Division of Medical Genetics and Genomics, the Children's Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.ORCID 0000-0002-2811-0194
Dongdong FanCollege of Life Sciences, Key Laboratory of Cell and Molecular Intelligent Design and Development of Zhejiang Province, Division of Medical Genetics and Genomics, the Children's Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.
Aifu LinCollege of Life Sciences, Key Laboratory of Cell and Molecular Intelligent Design and Development of Zhejiang Province, Division of Medical Genetics and Genomics, the Children's Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.ORCID 0000-0002-3968-3617
Lixin XiangCollege of Life Sciences, Key Laboratory of Cell and Molecular Intelligent Design and Development of Zhejiang Province, Division of Medical Genetics and Genomics, the Children's Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.ORCID 0000-0002-7136-7729
Ye ChenCollege of Life Sciences, Key Laboratory of Cell and Molecular Intelligent Design and Development of Zhejiang Province, Division of Medical Genetics and Genomics, the Children's Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.ORCID 0000-0003-3671-2504
Jianzhong ShaoCollege of Life Sciences, Key Laboratory of Cell and Molecular Intelligent Design and Development of Zhejiang Province, Division of Medical Genetics and Genomics, the Children's Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.ORCID 0000-0003-3483-1817

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spring viremia of carp virus (SVCV), a highly pathogenic rhabdovirus prevalent in fish, causes substantial mortality by evading host antiviral immunity; however, the underlying mechanisms remain incompletely understood. This study reveals a novel immune evasion strategy whereby the SVCV phosphoprotein (SVCV-P) hijacks the TBK1-IRF3 signaling axis via liquid-solid phase transition (LSPT), sequestering interferon regulatory factor 3 (IRF3) and inhibiting interferon (IFN) production. Upon stimulation, IRF3 facilitates TBK1 into functional liquid-liquid phase separation (LLPS) condensates, spatially enhancing IRF3 phosphorylation and downstream IFN responses. IRF3 acts as a scaffold via its DNA-binding domain (DBD) and intrinsically disordered region (IDR), while TBK1 incorporates via its kinase domain (KD), ubiquitin-like domain (ULD), and scaffold dimerization domain (SDD). Conversely, SVCV-P, driven by its IDRs and central domain (CD), undergoes robust LLPS, competitively recruiting TBK1 into SVCV-P-TBK1 condensates. These condensates merge with IRF3-TBK1 droplets, forming SVCV-P-TBK1-IRF3 ternary condensates. These subsequently undergo LSPT, immobilizing IRF3 and preventing its nuclear translocation.

Indexed as

Interferon Regulatory Factor-3InterferonsPhosphoproteinsProtein Serine-Threonine KinasesRhabdoviridaeRhabdoviridae InfectionsViral ProteinsZebrafish ProteinsAnimalsCarpsFish DiseasesHumansImmune EvasionPhase SeparationPhosphorylationSignal TransductionInterferon Regulatory Factor-3InterferonsIrf3 protein, zebrafishPhosphoproteinsProtein Serine-Threonine KinasesViral ProteinsZebrafish Proteinsinterferon regulationphase separationSVCV phosphoproteinTBK1-IRF3 signaling axisviral evasion

Identifiers

PMID41363845
PMCPMC12817906

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.