Evidence map›Paper›PMID 41362846›Full record

ArticleTechnical innovations & patient support in radiation oncology2025

Improved PTV coverage and OAR sparing with stereotactic MRI-guided online adaptive radiotherapy with elective fields in pancreatic cancer.

Dinah Konnerth, Hidehiro Hojo, Frederik Fuchs, Mohamed A Shouman, Diana-Coralia Dehelean, Aurélie Gaasch, Franziska Walter, Chukwuka Eze, Sebastian N Marschner, Sina Mansoorian and 7 more

Abstract read
In one paragraph

Article in Technical innovations & patient support in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Dinah KonnerthDepartment of Radiation Oncology, University Hospital LMU, Munich, Germany.
Hidehiro HojoDepartment of Radiation Oncology, University Hospital LMU, Munich, Germany.
Frederik FuchsDepartment of Radiation Oncology, University Hospital LMU, Munich, Germany.
Mohamed A ShoumanDepartment of Radiation Oncology, University Hospital LMU, Munich, Germany.
Diana-Coralia DeheleanDepartment of Radiation Oncology, University Hospital LMU, Munich, Germany.
Aurélie GaaschDepartment of Radiation Oncology, University Hospital LMU, Munich, Germany.
Franziska WalterDepartment of Radiation Oncology, University Hospital LMU, Munich, Germany.
Chukwuka EzeDepartment of Radiation Oncology, University Hospital LMU, Munich, Germany.
Sebastian N MarschnerDepartment of Radiation Oncology, University Hospital LMU, Munich, Germany.
Sina MansoorianDepartment of Radiation Oncology, University Hospital LMU, Munich, Germany.
Sebastian H MaierDepartment of Radiation Oncology, University Hospital LMU, Munich, Germany.
Vanessa da Silva MendesDepartment of Radiation Oncology, University Hospital LMU, Munich, Germany.
Jan HofmaierDepartment of Radiation Oncology, University Hospital LMU, Munich, Germany.
Maximilian NiyaziDepartment of Radiation Oncology, University Hospital LMU, Munich, Germany.
Claus BelkaDepartment of Radiation Oncology, University Hospital LMU, Munich, Germany.
Stefanie CorradiniDepartment of Radiation Oncology, University Hospital LMU, Munich, Germany.
Paul RogowskiDepartment of Radiation Oncology, University Hospital LMU, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Ablative stereotactic radiotherapy for pancreatic ductal adenocarcinoma (PDAC) is limited by adjacent radiosensitive organs at risk (OAR) that exhibit significant daily positional variability. This study aims to investigate the benefit of stereotactic MRI-guided online adaptive radiotherapy (SMART) with elective fields on target coverage and OAR dose sparing in patients with PDAC. Methods: We retrospectively analysed 62 consecutive PDAC patients treated with SMART between 2020-2024, totaling 310 fractions. For each fraction, a non-adapted plan (PLAN Results: Prescribed doses were 40 Gy (71 %) and 33 Gy (29 %) over five fractions. A simultaneous integrated boost approach was used in 47 % of patients. The PLAN Conclusion: For the vast majority of PDAC patients treated with stereotactic radiotherapy with elective fields daily online adaptation enhances target coverage and OAR sparing.

Indexed as

DosimetryOAROnline adaptationPancreatic cancerSBRTSMART

Identifiers

PMID41362846
PMCPMC12681930

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.