Evidence map›Paper›PMID 41362758›Full record

ArticleiScience2025

TrkB modulates parvalbumin interneuron excitability and spatial memory enhancement induced by long-term rhythmic light flicker.

Yunxuan Wang, Jun Ju, Yifan Pan, Lihai Fan, Shiyu Wu, Shuifa Chen, Jinghong Chen, Hai Yan, Wenhao Ouyang, Kun Song and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yunxuan WangBrain Research Centre, Department of Neurobiology, School of Life Sciences, Southern University of Science and Technology, 1088 Xueyuan Boulevard, Nanshan District, Shenzhen 518055, Guangdong, P.R. China.
Jun JuBrain Research Centre, Department of Neurobiology, School of Life Sciences, Southern University of Science and Technology, 1088 Xueyuan Boulevard, Nanshan District, Shenzhen 518055, Guangdong, P.R. China.
Yifan PanBrain Research Centre, Department of Neurobiology, School of Life Sciences, Southern University of Science and Technology, 1088 Xueyuan Boulevard, Nanshan District, Shenzhen 518055, Guangdong, P.R. China.
Lihai FanBrain Research Centre, Department of Neurobiology, School of Life Sciences, Southern University of Science and Technology, 1088 Xueyuan Boulevard, Nanshan District, Shenzhen 518055, Guangdong, P.R. China.
Shiyu WuBrain Research Centre, Department of Neurobiology, School of Life Sciences, Southern University of Science and Technology, 1088 Xueyuan Boulevard, Nanshan District, Shenzhen 518055, Guangdong, P.R. China.
Shuifa ChenBrain Research Centre, Department of Neurobiology, School of Life Sciences, Southern University of Science and Technology, 1088 Xueyuan Boulevard, Nanshan District, Shenzhen 518055, Guangdong, P.R. China.
Jinghong ChenBrain Research Centre, Department of Neurobiology, School of Life Sciences, Southern University of Science and Technology, 1088 Xueyuan Boulevard, Nanshan District, Shenzhen 518055, Guangdong, P.R. China.
Hai YanBrain Research Centre, Department of Neurobiology, School of Life Sciences, Southern University of Science and Technology, 1088 Xueyuan Boulevard, Nanshan District, Shenzhen 518055, Guangdong, P.R. China.
Wenhao OuyangBrain Research Centre, Department of Neurobiology, School of Life Sciences, Southern University of Science and Technology, 1088 Xueyuan Boulevard, Nanshan District, Shenzhen 518055, Guangdong, P.R. China.
Kun SongBrain Research Centre, Department of Neurobiology, School of Life Sciences, Southern University of Science and Technology, 1088 Xueyuan Boulevard, Nanshan District, Shenzhen 518055, Guangdong, P.R. China.
Sheng-Tao HouBrain Research Centre, Department of Neurobiology, School of Life Sciences, Southern University of Science and Technology, 1088 Xueyuan Boulevard, Nanshan District, Shenzhen 518055, Guangdong, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-term 40 Hz light flicker stimulation enhances parvalbumin (PV) interneuron activity in the hippocampal dentate gyrus (DG), increasing GABA release, promoting adult neurogenesis, and improving spatial memory in mice. This stimulation upregulates brain-derived neurotrophic factor (BDNF) in the DG granule cells, while the expression of its receptor, TrkB, in PV interneurons remains unchanged. Knock-down TrkB expression in PV interneurons abolished the light flicker-evoked enhancement of PV excitability and inhibitory transmission to granule cells, highlighting the critical role of TrkB signaling in the function of PV interneurons. TrkB knockdown also reduced the increase in low gamma oscillations and blocked the improvement in spatial learning induced by light flicker. Mechanistically, TrkB modulates the flicker-evoked increase in sustained (I

Indexed as

behavioral neuroscienceBiological sciencesCellular neuroscienceNatural sciencesneuroscienceSystems neuroscience

Identifiers

PMID41362758
PMCPMC12682287

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.