Evidence map›Paper›PMID 41362739›Full record

ArticleInternational journal of biological sciences2026

Procyanidin Suppresses Tumor Growth by Activating the B-Cell MAPK Pathway through Remodulation of the Gut Microbiota and Metabolites in Hepatocellular Carcinoma.

Ran Huo, Chen-Zheng Gu, Yang Liu, Zi-Xian Wei, Te Liu, Jie Zhu, Lin Ding, Yu Liu, Chu-Yu Wang, Yi-Ni Li and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ran HuoDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Chen-Zheng GuDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Yang LiuDepartment of Pancreatic and Gastrointestinal Surgery Division, Ningbo No.2 Hospital, Ningbo, China.
Zi-Xian WeiDepartment of Hepatobiliary and Pancreatic Surgery, Qunli Branch, the First Afiliated Hospital of Harbin Medical University, Harbin, China.
Te LiuShanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jie ZhuDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Lin DingDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Yu LiuDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Chu-Yu WangDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Yi-Ni LiDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Xin-Yi HeDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Wen-Jing YangDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Bei-Li WangDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Yun-Wei WeiDepartment of Pancreatic and Gastrointestinal Surgery Division, Ningbo No.2 Hospital, Ningbo, China.
Wei GuoDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mortality of hepatocellular carcinoma (HCC) is high. Plant-derived bioactive compounds have emerged as potential therapies for HCC. Procyanidin (PAC) has been shown to possess immune-modulating and anti-tumor properties. However, the role and mechanism of total PAC in treating HCC remain unclear. We established subcutaneous and orthotopic HCC mouse models to assess the effect of PAC on tumor growth. Multi-omics analyses and

Indexed as

BiflavonoidsB-LymphocytesCarcinoma, HepatocellularCatechinGastrointestinal MicrobiomeLiver NeoplasmsMAP Kinase Signaling SystemProanthocyanidinsAnimalsCell Line, TumorHumansMaleMiceMice, Inbred BALB CTumor MicroenvironmentBiflavonoidsCatechinProanthocyanidinsprocyanidin5-hydroxytryptophanB cellsgut microbiotahepatocellular carcinomaMAPK pathwayprocyanidin

Identifiers

PMID41362739
PMCPMC12681853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.