Evidence map›Paper›PMID 41362666›Full record

ArticleMethodsX2025

The BCG

Frederik Schaltz-Buchholzer, Ole Bæk, Amrit Singh, Elsi Cá, Isaquel da Silva, Peter Aaby, Christine Stabell Benn, Tobias R Kollmann, Nelly Amenyogbe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MethodsX, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Frederik Schaltz-BuchholzerBandim Health Project, Apartado 861, 1004 Bissau codex, Bissau, Guinea-Bissau.
Ole BækComparative Pediatrics, Faculty of Health Sciences, University of Copenhagen, Grønnegårdsvej 15, 1870 Frederiksberg C, Copenhagen, Denmark.
Amrit SinghDepartment of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Medical Sciences Block C, 217 - 2176 Health Sciences Mall, Vancouver BC V6T 1Z3, Canada.
Elsi CáBandim Health Project, Apartado 861, 1004 Bissau codex, Bissau, Guinea-Bissau.
Isaquel da SilvaBandim Health Project, Apartado 861, 1004 Bissau codex, Bissau, Guinea-Bissau.
Peter AabyBandim Health Project, Apartado 861, 1004 Bissau codex, Bissau, Guinea-Bissau.
Christine Stabell BennBandim Health Project, OPEN, Department of Clinical Research, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.
Tobias R KollmannDept. of Microbiology & Immunology, Dalhousie University, Halifax B3H 4R2, Canada.
Nelly AmenyogbeDept. of Microbiology & Immunology, Dalhousie University, Halifax B3H 4R2, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of Bacillus Calmette-Guérin (BCG) vaccine against tuberculosis (TB) spans more than a century. Besides protection against severe paediatric TB, randomized trials and novel advances within innate immunology documented that BCG has beneficial non-specific effects, providing protection against non-TB infections. Since paediatric intradermal BCG vaccination has proved unable to contain adult pulmonary tuberculosis, several novel TB vaccines are under development, most of which build upon BCG. BCG's status as an essential remedy against TB will therefore be maintained, but despite many decades of near-universal intradermal use, the local responses to BCG in the skin have not been thoroughly elucidated. We therefore developed appropriate methods to capture the localised skin events at the cellular and molecular level after intradermal BCG vaccination. This work informs future studies to identify the immunological events induced following administration of BCG to accelerate development of improved or new vaccines against

Indexed as

Bacillus Calmette-GuérinLiquid biopsyLocalized cellular and molecular skin effectsMultiomicsNon-specific effectsPunch skin biopsy

Identifiers

PMID41362666
PMCPMC12681442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.