Evidence map›Paper›PMID 41362615›Full record

ArticleiScience2025

Ruminal microbial dysbiosis induces mastitis in dairy goats by activating oxidative stress and ferritinophagy-ferroptosis.

Yuhong He, Wei Zhang, Can Zhang, Nier Su, Zeming Zhou, Chong Peng, Chongshan Yuan, Yunhe Fu, Xiaoyu Hu, Yue Zhang

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In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuhong HeDepartment of Anesthesiology, China-Japan Union Hospital of Jilin University, Erdao District, 126 Sendai Street, Changchun, Jilin Province 130033, China.
Wei ZhangDepartment of Anesthesiology, China-Japan Union Hospital of Jilin University, Erdao District, 126 Sendai Street, Changchun, Jilin Province 130033, China.
Can ZhangDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province 130062, China.
Nier SuDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province 130062, China.
Zeming ZhouDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province 130062, China.
Chong PengDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province 130062, China.
Chongshan YuanDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province 130062, China.
Yunhe FuDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province 130062, China.
Xiaoyu HuDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province 130062, China.
Yue ZhangCollege of Animal Science and Technology, Jilin Agriculture Science and Technology University, Jilin City, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies indicate that ruminal microbiota dysbiosis plays a significant role in the development of mastitis in ruminants, though the exact mechanisms remain incompletely understood. In this study, a high-concentration (HC) diet led to subacute ruminal acidosis (SARA) in dairy goats, as evidenced by prolonged daily periods of ruminal pH below 5.8. The HC group exhibited disrupted ruminal microbiota, elevated serum levels of LPS, TNF-α, and IL-1β, and a markedly increased milk somatic cell count (SCC) exceeding 500,000/mL, indicating mastitis. Ruminal microbiota transplantation (RMT) from HC goats induced mastitis in mice, which is associated with oxidative stress and ferritinophagy-ferroptosis. The administration of ferrostatin-1 (Fer-1) alleviated mastitis in mice. Further

Indexed as

Cell biologyMicrobiology

Identifiers

PMID41362615
PMCPMC12682052

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.