ArticleiScience2025
Parvalbumin interneurons drive depth-dependent vascular responses.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Simultaneous in vivo imaging of CaThe journal of physiological sciences : JPS · 2026Article
- Molecular alterations in chondrolectin-containing somatostatin neurons in schizophrenia differ based on circuit context.Molecular psychiatry · 2026Article
- Parvalbumin interneurons contribute to spontaneous hemodynamic fluctuations.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- A hypoxia-sensitive medullary nucleus modulates cerebral blood flow via a disynaptic pathway to cortex.bioRxiv : the preprint server for biology · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
Understanding how neurons regulate cerebral blood flow (CBF) is crucial for interpreting brain hemodynamic imaging signals. Although parvalbumin (PV) interneurons strongly influence network activity, their effects on CBF appear variable, particularly during natural sensory stimulation and resting state. Using two-photon imaging in awake mice, we assessed PV interneuron effects on vascular tone across cortical depths during evoked and spontaneous activity. Optogenetic PV activation produced rapid vasodilation in the superficial cortex (<250 μm) and slow, delayed vasodilation in the middle cortex (250-400 μm). Chemogenetic PV suppression revealed that PV interneurons did not drive the rapid hemodynamic increase to sustained sensory input but did contribute to superficial vasodilation following brief stimuli. During spontaneous activity, synchronized PV interneuron activity predicted depth-specific arteriolar changes more strongly than non-PV neurons. These findings demonstrate a depth-dependent role for PV interneurons in regulating CBF and refine our understanding of neurovascular coupling.
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Registered trials
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