ArticleMaterials today. Bio2025
Dual-wavelength UV photofunctionalization of 3D-printed Ti6Al4V porous bone implant enhances osseointegration via adhesion-cytoskeleton-nuclear mechanotransduction.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Phase-Separated Nanoarchitecture of Adhesion-Cytoskeleton Force Coupling Reforms Nuclear Spatiotemporal Posture Conformation and Mechanotransduction of Osteosarcoma on Biofunctional Microarrays.Advanced healthcare materials · 2026Article
- Bioengineering DNA-based hydrogels for regenerative medicine: A review of programmable design, chemical synthesis and therapeutic potential.Materials today. Bio · 2026Review
- Effects of UV Photo-Functionalization of Titanium Dental Implants on Osteoblast Responses In Vitro.Biomimetics (Basel, Switzerland) · 2026Article
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11 authors.
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Abstract
Orthopedic implants can be modified with ultraviolet (UV) photofunctionalization to improve osseointegration via force-sensing mechanotransduction in the microenvironment. Meanwhile, few researches have elucidated how UV wavelengths affect the photon-functionalized efficiency to promote synergistic osseointegration. Therefore, three-dimensional (3D)-printed porous Ti6Al4V implants were photofunctionalized with UVC (270 nm; G270), UVA (365 nm; G365), or UV-AC (270 + 365 nm; GU) to investigate the influence of different UV wavelengths on synergistic osseointegration via mechanotransduction. The alkaline phosphatase activity, hydrophilicity, and cytocompatibility of the porous Ti6Al4V implants were considerably higher following UV-AC treatment than following UVA or UVC treatment. Increased bone-implant contact and mineralized (osteoid) bone ratios further showed that UV-AC therapy significantly improved the osteointegration of porous Ti6Al4V implants in an in vivo rabbit condyle defect model. These results suggested that synergistic osteogenic effect of UV-AC irradiation could successfully promote the osseointegration by osteogenic staining and Micro-CT. The surface modification of 3D-printed titanium alloys using multi-wavelength UV functionalization for osseointegration enhancement was supported through adhesion-cytoskeleton-nuclear coupling via force-sensing mechanotransduction in bone tissue microenvironment. This study may be helpful for understanding the photon-functionalized osseointegration of 3D-printed scaffolds via force-sensing mechanotransduction in bone microenvironment.
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