ArticleJournal of Alzheimer's disease reports
Metabolic factors, gut microbiota, and cognitive performance: Mendelian randomization analysis.
Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The associations between several metabolic factors, gut microbiota (GM), and cognitive performance have not been clearly identified. This study investigates their associations and GM's mediating effects. Objective: This study aimed to investigate the causal effects of key metabolic factors on cognitive performance and to determine whether gut microbiota mediate these associations. Methods: Genetic variants linked to four metabolic factors [body mass index (BMI), basal metabolic rate (BMR), systolic blood pressure (SBP), two-hour glucose], GM, and cognitive performance were selected from genome-wide association studies (GWAS). Univariable Mendelian randomization (MR) and mediation MR analyses were applied. Results: We found a protective effect of body metabolic rate (β = 0.061; 95% CI: 0.029, 0.093; p = 0.0002) and risk effect of body mass index (BMI, β = -0.047; 95% CI: -0.074, -0.019; p = 0.0009), systolic blood pressure (β = -0.049; 95% CI: -0.084, -0.014; p = 0.0063), and two-hour glucose (β = -0.043; 95% CI: -0.070, -0.016; p = 0.0017) on cognitive performance. In addition, the 2-step MR analysis further showed that the BMI-effect on cognitive performance was partially mediated by Rikenellaceae family, with a mediated proportion of 14.03% (95% CI: 0.99%, 27.06%; p < 0.05). Conclusions: Our findings suggest that several metabolic factors influence cognitive performance, with gut microbiota potentially mediating these effects. These results provide insights into potential targets and useful biomarkers for understanding the pathogenesis and developing interventions for cognitive health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.