ArticleThe Lancet regional health. Western Pacific2025
Comprehensive epidemiological analysis of severe fever with thrombocytopenia syndrome in Japan, 2013-2023: descriptive observational study.
Article in The Lancet regional health. Western Pacific, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- First autochthonous case of severe fever with thrombocytopenia syndrome in Hokkaido, the northernmost island of Japan.IJID regions · 2026Article
- Meteorological and environmental factors associated with the spatiotemporal risk of severe fever with thrombocytopenia syndrome in Japan: A prefecture-level time-series modeling study.One health (Amsterdam, Netherlands) · 2026Article
- Phylogeographic epidemiology of Dabie bandavirus in East Asia: divergent transmission networks and genotype‑linked clinical severity.Infectious diseases of poverty · 2026Article
- Genotype-Specific Amino Acid Signatures in the Gn/Gc Glycoprotein of Severe Fever with Thrombocytopenia Syndrome Virus Associated with Neurological Symptoms.Pathogens (Basel, Switzerland) · 2026Article
- Genomic Characterization of a Novel Victorivirus Detected in a Sample Derived From a Human-Biting Tick in Japan.Microbiology and immunology · 2026Article
- Epidemiology of Lyme disease, a growing tick-borne disease of concern, in Japan from May 2013 to March 2024: a descriptive study.IJID regions · 2026Article
- Tick-small mammal relationships in urban and forest environments in Yamagata Prefecture, Japan: First confirmation of the establishment of southern tick species in northern Japan.International journal for parasitology. Parasites and wildlife · 2026Article
- Article
- Development and validation of an interpretable machine learning model for the early diagnosis of invasive pulmonary aspergillosis in patients with severe fever with thrombocytopenia syndrome: a retrospective cohort study.Frontiers in cellular and infection microbiology · 2026Article
- Research progress on antiviral drugs and vaccines for severe fever with thrombocytopenia syndrome.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne zoonotic disease that poses a serious public health challenge in several Asian countries. In this study, we aimed to describe the recent epidemiological characteristics of SFTS in Japan using denominator-based test data. Methods: We analysed reported SFTS case-patients in Japan using national surveillance data from March 2013 to April 2024. The case-fatality ratio (CFR) was calculated using the National Vital Statistics Surveillance System (NVSSS) for 2013-2022. Trends in test numbers and positivity rates were examined using data from annual reports and public health institute surveys. Findings: During the study period, 931 case-patients were reported, including 11 veterinary healthcare workers. The annual notification rate rose from 3.12 per ten million in 2013 to 10.46 in 2023, with 30 (64%) estimated infection prefectures, primarily in western and central Japan. The NVSSS CFRs remained high at approximately 20%. Test numbers and positive results increased from 2013 (n = 350, n = 41) to 2022 (n = 923, n = 95); however, positivity decreased from 12% to 10%. Interpretation: The annual SFTS notification rate increased, and infection regions expanded between 2013 and 2023, with persistently high CFRs and increased testing. Veterinary healthcare workers appear to be a potential high-risk group. These findings highlight that SFTS remains a public health concern in Japan, requiring a comprehensive health strategy. Funding: This work was supported by the Japan Society for the Promotion of Science Kakenhi Grants-in-Aid for Young Scientists (grant number: 24K19277).
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