ArticleAmerican heart journal plus : cardiology research and practice2026
Integration of BNP and blood glucose for identifying coronary flow reserve impairment: A cardiovascular-kidney-metabolic perspective.
Article in American heart journal plus : cardiology research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Endothelial Mitochondrial Dysfunction in INOCA and Coronary Microvascular Dysfunction: Mechanisms, Sex Differences, and Therapeutic Implications.Journal of cardiovascular development and disease · 2026Review
- Cardiovascular-kidney-metabolic syndrome: a comprehensive review of pathophysiology, epidemiology, diagnosis, and management.Cardiovascular diabetology · 2026Review
- Symptom phenotypes and coronary microvascular function in non-obstructive coronary artery disease: Insights beyond epicardial ischemia.American heart journal plus : cardiology research and practice · 2026Article
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17 authors.
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Abstract
Cardiovascular-kidney-metabolic (CKM) syndrome may predispose patients to coronary microvascular dysfunction (CMD) through systemic microvascular injury. We investigated the association between CKM risk factors and CMD, focusing on the diagnostic performance of accessible biomarkers. In this exploratory analysis, we retrospectively analyzed 65 patients who underwent invasive coronary physiological assessment with thermodilution-derived coronary flow reserve (CFR) and index of microcirculatory resistance (IMR). Clinical variables included casual blood glucose, B-type natriuretic peptide (BNP), and the urine albumin-to-creatinine ratio (ACR), along with echocardiographic indices of diastolic function. Among the 65 patients, 20 (31 %) had impaired CFR. BNP (AUC = 0.74; 95 % confidence interval, CI, 0.60-0.88) and casual blood glucose (area under the curve, AUC = 0.64; 95 % CI, 0.49-0.80) showed diagnostic accuracy for impaired CFR of <2.0, while ACR improved model performance when combined with BNP or E/e'. The combination of BNP and casual glucose significantly improved diagnostic performance compared with either marker alone (AUC = 0.83 vs. 0.75; 95 % CI, 0.73-0.93;
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