ArticleBMJ neurology open2025
Stiff-person spectrum disorder induced by shingles: a case report.
Article in BMJ neurology open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Stiff Person Syndrome: Bridging Neuroimmunology and Rehabilitation for Improved Patient Outcomes.Archives of internal medicine research · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Stiff-person spectrum disorder (SPSD) is a rare autoimmune neurological disorder characterised by progressive rigidity, muscle co-contractions and spasms; 5%-10% are paraneoplastic. Few infection-related SPSD cases have been reported. Case presentation: We describe a 56-year-old woman who developed SPSD after herpes zoster. Eight days after rash onset, she experienced persistent lower-limb tonic spasms with co-contractions, autonomic symptoms and elevated anti-glutamic acid decarboxylase antibodies in serum and cerebrospinal fluid. Immunotherapy with repeated high-dose intravenous immunoglobulin and methylprednisolone pulses, along with continuous benzodiazepines and epidural analgesia, led to gradual improvement over 3 months. Conclusions: Pain from herpes zoster may have amplified muscle co-contractions via withdrawal and crossed extension reflexes, exacerbating impaired reciprocal inhibition in SPSD. Clinicians should consider optimal pain control in addition to immunotherapy for SPSD triggered by infection.
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