ArticleAnnals of laboratory medicine2026
Whole-Genome and Targeted Sequencing of 75 Drug-Resistant
Article in Annals of laboratory medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Bridging Genotypic and Phenotypic Drug Susceptibility Testing forAnnals of laboratory medicine · 2026Article
- First Report of KPC-2-Producing Hafnia paralvei: Evidence of Horizontal Gene Transfer fromAnnals of laboratory medicine · 2026Article
- Whole-Genome Sequencing and Phenotypic Drug Susceptibility Testing of Bedaquilin, Delamanid, Pretomanid, and Linezolid in Drug-ResistantPathogens (Basel, Switzerland) · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Tuberculosis (TB), an infectious disease caused by Methods: We evaluated and compared phenotypic drug susceptibility testing (pDST) and genotypic drug susceptibility testing (gDST) using whole-genome sequencing (WGS) and targeted sequencing in 75 clinical Results: We detected resistance-associated mutations in 98.7% of INH- and RIF-resistant isolates, with a high degree of concordance between the pDST and gDST results for most drugs. However, PZA results were discrepant for 16 isolates. Conclusions: Our findings highlight the potential of WGS and targeted sequencing as powerful tools for diagnosing TB drug resistance and emphasize the need for further validation before their routine implementation in clinical settings.
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