Evidence map›Paper›PMID 41362017›Full record

ArticleThe New phytologist2026

Identification of a novel link connecting indole-3-acetamide with abscisic acid biosynthesis and signaling.

José Moya-Cuevas, Paloma Ortiz-García, Adrián González Ortega-Villaizán, Irene Viguera-Leza, Andrés Pérez-González, Javier Paz-Ares, Carlos Alonso-Blanco, Jesús Vicente-Carbajosa, Stephan Pollmann

Abstract read
In one paragraph

Article in The New phytologist, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

José Moya-Cuevas *Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentación (INIA/CSIC), Campus de Montegancedo, 28223, Pozuelo de Alarcón (Madrid), Spain.ORCID https://orcid.org/0000-0001-9537-8556
Paloma Ortiz-García *Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentación (INIA/CSIC), Campus de Montegancedo, 28223, Pozuelo de Alarcón (Madrid), Spain.ORCID https://orcid.org/0000-0001-5007-4188
Adrián González Ortega-VillaizánCentro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentación (INIA/CSIC), Campus de Montegancedo, 28223, Pozuelo de Alarcón (Madrid), Spain.ORCID https://orcid.org/0000-0001-8221-6793
Irene Viguera-LezaCentro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentación (INIA/CSIC), Campus de Montegancedo, 28223, Pozuelo de Alarcón (Madrid), Spain.
Andrés Pérez-GonzálezCentro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentación (INIA/CSIC), Campus de Montegancedo, 28223, Pozuelo de Alarcón (Madrid), Spain.
Javier Paz-AresDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnología (CNB-CSIC), 28049, Madrid, Spain.ORCID https://orcid.org/0000-0003-0553-9745
Carlos Alonso-BlancoDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnología (CNB-CSIC), 28049, Madrid, Spain.ORCID https://orcid.org/0000-0002-4738-5556
Jesús Vicente-CarbajosaCentro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentación (INIA/CSIC), Campus de Montegancedo, 28223, Pozuelo de Alarcón (Madrid), Spain.ORCID https://orcid.org/0000-0002-6332-1712
Stephan PollmannCentro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentación (INIA/CSIC), Campus de Montegancedo, 28223, Pozuelo de Alarcón (Madrid), Spain.ORCID https://orcid.org/0000-0002-5111-4425

Funding

Spanish Ministry of Science and Innovation (MICIN) BFU2017-82826-RSpanish Ministry of Science and Innovation (MICIN) PID2020-119441RB-100Spanish Ministry of Science and Innovation (MICIN) PID2022-136893NB-I00Spanish Ministry of Science and Innovation (MICIN) RED2022-134917-TSpanish Ministry of Science and Innovation (MICIN) SEV-2016-0672
6 · The paper itself

Abstract

Plants orchestrate their developmental processes and responses to environmental stimuli through a sophisticated network of small signaling molecules, termed phytohormones. Among these, auxins are recognized for their role in promoting plant growth. However, indole-3-acetamide (IAM), an auxin precursor, has been observed to inhibit primary root elongation. The molecular mechanism underlying this inhibitory effect remains largely unexplored. A comprehensive genome-wide association study (GWAS) conducted on a highly diverse collection of 166 wild Arabidopsis accessions from the Iberian Peninsula has identified several genomic regions associated with reduced IAM sensitivity under controlled in vitro conditions. This study highlighted ABA3 and GA2ox2 as possible candidate genes. Molecular and structural analyses suggest that the inhibition of primary root elongation induced by IAM is intricately associated with the enhanced production of abscisic acid (ABA) involving ABA3. Studies employing mutant and reporter lines have confirmed that IAM activates ABA signaling, thereby revealing a novel interaction between the auxin precursor IAM and ABA and suggesting an independent role for IAM as a signaling molecule in plant hormone crosstalk.

Indexed as

Abscisic AcidArabidopsisIndolesSignal TransductionArabidopsis ProteinsGene Expression Regulation, PlantGenome-Wide Association StudyIndoleacetic AcidsMutationPlant RootsAbscisic AcidArabidopsis ProteinsindoleacetamideIndoleacetic AcidsIndolesabiotic stress responsenatural variationplant hormone crosstalkreverse geneticsroot growth inhibition

Identifiers

PMID41362017
PMCPMC12873522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.