ArticleTrials2025
The impact of DASH diet and concurrent training on cardiometabolic risk factors and gut microbiota in individuals with ischemic heart disease: a study protocol for a randomized controlled trial.
Article in Trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Cardiometabolic Health During the Climacteric Transition: A Narrative Review of Lifestyle, Physiological, and Nutritional Approaches.Healthcare (Basel, Switzerland) · 2026Review
- Diet, Physical Exercise, and Gut Microbiota Modulation in Metabolic Syndrome: A Narrative Review.Life (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIschemic heart disease (IHD) has a substantial burden on individuals and health system infrastructure worldwide. Meanwhile, mounting evidence has declared remarkable contrasts in gut microbiota between individuals with IHD and healthy counterparts. The Dietary Approaches to Stop Hypertension (DASH) might be one of the most reliable strategies to manage cardiometabolic risk factors. Nonetheless, no experiment has tested the impact of a DASH diet and exercise on gut microbiota composition in IHD individuals. Hence, we aim to explore the effects of a DASH diet and concurrent exercise on gut microbiota, oxidized LDL, and cardiometabolic risk factors among men.
methodsIn total, 48 men aged 40-70 years with IHD will be recruited in this parallel randomized, controlled, 2 × 2 factorial clinical trial. These patients will be randomly assigned to the following four intervention groups: DASH diet (D), concurrent exercise (E), concurrent DASH diet and exercise (DE), and control (usual care) (C) for 8 weeks. At baseline and the end of the study, stool samples and serum levels will be gathered to detect gut microbiota (Firmicutes, Bacteroidetes, Bifidobacteria, clostridium, Faecalibacterium prausnitzi, Bacteroidetes, and Akkermansia muciniphila) and cardiometabolic risk factors, as well as anthropometric measures, blood pressure, quality of life, 6-min walking test, and Beck Depression Inventory (BDI). DISCUSSION: Based on our information, the present study is the primary randomized controlled trial testing the impacts of short-term concurrent training and DASH diet on intestinal bacteria diversity and several cardiometabolic risk factors in men with IHD.
trial registrationIranian Registry of Clinical Trials (www.irct.ir, IRCT20181205041859N1). Registered on 29 September 2024.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.