Trial reportBMC surgery2025
Effects of different antibiotic strategies on postoperative inflammatory response and recovery in patients with acute appendicitis: a single-center, prospective, randomized controlled study.
Trial report in BMC surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
Abstract
objectiveTo evaluate the impact of different antibiotic regimens on postoperative outcomes in patients with acute appendicitis and assess the predictive value of preoperative procalcitonin (PCT) for postoperative fever.
methodsThis prospective randomized controlled trial enrolled patients with acute uncomplicated appendicitis. Participants were randomly assigned to three groups: no antibiotics, single preoperative dose, or full-course antibiotics (preoperative dose plus 3 days postoperative). Inflammatory markers, pain scores, length of stay, and complications were compared. ROC analysis assessed PCT’s predictive value for fever.
resultsOf 437 randomized patients, baseline characteristics were comparable. No significant differences were observed among groups in postoperative inflammatory markers (POD1 and POD3), length of hospital stay, pain scores, or complication rates (all P > 0.05). Preoperative PCT demonstrated excellent predictive value for postoperative fever (AUC = 0.852, sensitivity 76.2%, specificity 88.5%).
conclusionOmitting perioperative antibiotics did not compromise outcomes in laparoscopic appendectomy for uncomplicated appendicitis. Preoperative PCT effectively predicts postoperative fever, aiding clinical decision-making for antibiotic use.
trial registration: Chinese Clinical Trial Registry, ChiCTR2000032410. Registered on May 8, 2020.
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