Evidence map›Paper›PMID 41361801›Full record

Trial reportBMC anesthesiology2025

Oxycodone reduces postoperative pulmonary complications compared to sufentanil in high-risk patients with pulmonary dysfunction: a randomized clinical trial.

Zhoutong Sun, Yijun Chen, Yuxing Tu, Binbin Zhu, Xixi Chen, Jiahuan Chen, Yajun Ding, Shimeng Dong, Lu Sun, Juan Yi

Abstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhoutong SunDepartment of Anesthesiology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo, 315000, China.
Yijun ChenDepartment of Anesthesiology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo, 315000, China. fyychenyijun@nbu.edu.cn.
Yuxing TuHealth Science Center, Ningbo University, Ningbo, 315211, China.
Binbin ZhuDepartment of Anesthesiology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo, 315000, China.
Xixi ChenDepartment of Anesthesiology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo, 315000, China.
Jiahuan ChenHealth Science Center, Ningbo University, Ningbo, 315211, China.
Yajun DingDepartment of Anesthesiology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo, 315000, China.
Shimeng DongDepartment of Anesthesiology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo, 315000, China.
Lu SunDepartment of Anesthesiology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo, 315000, China.
Juan YiDepartment of Anesthesiology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo, 315000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the effects of oxycodone versus sufentanil on postoperative pulmonary complications (PPCs) in patients with preoperative pulmonary dysfunction undergoing laparoscopic gastrointestinal surgery.

methodsThis single-center, double-blind, randomized, parallel controlled trial was conducted at the First Affiliated Hospital of Ningbo University in Ningbo, China. A total of 142 patients with preoperative pulmonary dysfunction who were scheduled to receive elective laparoscopic gastrointestinal surgery (including Da Vinci robot-assisted surgery) were enrolled between June 6, 2024, to June 30, 2025. Patients were randomized to receive intraoperative oxycodone (0.2 mg/kg) or sufentanil (0.4 µg/kg) during anesthesia induction, and oxycodone 0.1 mg/kg/sufentanil 0.2 µg /kg thirty minutes prior to the end of surgery, followed by PCIA with oxycodone (0.5 mg/kg diluted to 100 mL) or sufentanil (1 µg/kg diluted to 100 mL), with a background infusion of 2 mL/h, bolus 2 mL, and lockout 15 min. The primary outcome was the incidence of PPCs within 30 days after surgery.

resultsAmong 142 patients enrolled, 71 were randomized to receive intraoperative oxycodone, and 71 were randomized to receive sufentanil. In total, 7 patients were excluded and 135 patients were included in the ITT analysis. The incidence rate of PPCs was significantly lower in the oxycodone group compared to the sufentanil group (38.2% [26 of 68] vs. 56.7% [38 of 67]; relative risk = 0.67 [95% CI, 0.47 to 0.97]; P < 0.05). The incidence of PONV was also lower in the oxycodone group (16.2% vs 32.8%; relative risk = 0.49 [95% CI, 0.26 to 0.94]; P < 0.05). Pain scores at each time point and Opioid consumption within 48 h postoperatively were comparable between the oxycodone group and the sufentanil group. No statistically significant differences were observed between the two groups regarding postoperative rehabilitation metrics, including time to first flatus and length of hospital stay.

conclusionsCompared with sufentanil, oxycodone significantly reduced PPCs incidence in high-risk patients with pulmonary dysfunction without compromising analgesia or recovery, suggesting its utility in perioperative lung-protective strategies.

trial registrationRegistration number: ChiCTR2500099262. Registration date: March 20, 2025(Retrospectively registered).

Indexed as

Analgesics, OpioidLung DiseasesOxycodonePostoperative ComplicationsSufentanilAdultAgedDigestive System Surgical ProceduresDouble-Blind MethodFemaleHumansLaparoscopyMaleMiddle AgedAnalgesics, OpioidOxycodoneSufentanilLaparoscopic gastrointestinal surgeryOxycodonePostoperative pulmonary complicationsPulmonary dysfunctionRandomized controlled trialSufentanil

Identifiers

PMID41361801
PMCPMC12801554

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.