ArticleBMC pediatrics2025
Clinical features and health-related quality of life in children with sickle cell disease in Khartoum, Sudan.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSickle cell disease (SCD), a chronic hematologic disorder, is linked to higher morbidity and mortality rates. SCD is thought to impact 0.8% to 30% of Sudanese, making it one of the most common genetic diseases in the country. Patients with sickle cell disease may experience negative effects from the disease. In this study, children with SCD were evaluated at the selected hospitals in Khartoum state to assess their health-related quality of life (HRQOL). MATERIALS AND
methodsA cross-sectional facility-based study was conducted at five governmental pediatric hospitals in Khartoum state and their referral clinics. A four-section questionnaire (sociodemographic information, clinical characteristics, barriers to accessing health care, and the standardized PedQL™ Generic Core Scale) was employed. Total coverage was used. The statistical software for social sciences (SPSS) was used to analyze the data and determine the correlation between the variables.
resultsWe included 336 children with sickle cell disease, 191 (56.8%) males. Most participants were from Gaafar Ibnauf Specialized Hospital (n = 286, 85.1%). The majority were outpatients (77.4%), and 52.7% had a family history of the disease. Blood transfusions were required for 59.5% of patients, while 83.0% never needed exchange transfusions. The most common initial manifestation was painful crises (55.7%), while arthritis (49.4%) became a frequent symptom. The median total HRQOL score was 73.75 [57.50, 87.50]. The highest median HRQOL scores were in East Darfur, River Nile, and Central Darfur, while the lowest were in White Nile and Blue Nile. Factors significantly influencing HRQOL included hospital setting, number of affected siblings, rural residence, and father's employment. Linear regression showed that having more affected siblings was associated with higher HRQOL, while rural residence lowered HRQOL in older children. Father's employment improved HRQOL in younger children, while consanguinity had a negative impact.
conclusionsChildren with SCD had poor HRQOL, with low scores across multiple HRQOL domains. Factors such as consanguinity and father's unemployment negatively affected patients' HRQOL. Interventions are required to address such factors, and to alleviate the impact of barriers to healthcare access.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.