Evidence map›Paper›PMID 41361707›Full record

ArticleChinese journal of integrative medicine2026

Total Flavonoids of Litchi chinensis Sonn. Seed Improves Hepatic Fibrosis by Inhibiting PANoptosis.

Yan Tang, Ting Wang, Min-Chao Feng, Jun-Wen Gong, Mei-Wen Tang, Guo-Zhong Chen, Ma-Ling Si, Jian-Fang Feng, Wei-Sheng Luo

Abstract read
PubMed Publisher
In one paragraph

Article in Chinese journal of integrative medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yan TangDepartment of Gastroenterology, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning, 530023, China.
Ting WangThe Graduate School, Guangxi University of Traditional Chinese Medicine, Nanning, 530200, China.
Min-Chao FengThe Second Clinical School, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Jun-Wen GongThe Graduate School, Guangxi University of Traditional Chinese Medicine, Nanning, 530200, China.
Mei-Wen TangThe Graduate School, Guangxi University of Traditional Chinese Medicine, Nanning, 530200, China.
Guo-Zhong ChenDepartment of Gastroenterology, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning, 530023, China.
Ma-Ling SiXiangxing College, Hunan University of Traditional Chinese Medicine, Changsha, 411105, China.
Jian-Fang FengSchool of Pharmacy, Guangxi University of Traditional Chinese Medicine, Nanning, 530200, China.
Wei-Sheng LuoThe Graduate School, Guangxi University of Traditional Chinese Medicine, Nanning, 530200, China. 4011188@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the therapeutic benefits and possible mechanism of total flavonoids of Litchi chinensis Sonn. seed (TFLS) on hepatic fibrosis (HF) in vivo and in vitro.

methodsA carbon tetrachloride (CCl

resultsIn CCl

conclusionTFLS might ameliorate HF by targeting ZBP1 to suppress PANoptosis, highlighting its multi-modal regulation of apoptosis, pyroptosis, and necroptosis.

Indexed as

FlavonoidsLitchiLiver CirrhosisSeedsAnimalsApoptosisCarbon TetrachlorideCell LineHepatic Stellate CellsLiverMaleRatsRats, Sprague-DawleyTransforming Growth Factor beta1Carbon TetrachlorideFlavonoidsTransforming Growth Factor beta1Chinese medicinehepatic fibrosisPANoptosistotal lavonoids of Litchi chinensis Sonn. seedZ-DNA binding protein 1

Identifiers

PMID41361707

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.