Evidence map›Paper›PMID 41361667›Full record

SynthesisChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2025

Efficacy and safety of endoscopic third ventriculostomy with choroid plexus cauterization compared to ventriculoperitoneal shunting in pediatric hydrocephalus: a systematic review and meta-analysis with subgroup analysis.

Kenzo Ogasawara Donato, Luciano Falcão, Rafael Andrade Sampaio Silva, Akio Ogasawara Donato, André Nishizima, Filipe Virgílio Ribeiro, Mariana Letícia de Bastos Maximiano, Anderson Matheus Pereira da Silva, Mariana Lee Han, Ocílio Ribeiro Gonçalves and 3 more

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Publisher
In one paragraph

Synthesis in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kenzo Ogasawara DonatoBahiana School of Medicine and Public Health, Department of Medicine, Salvador, Bahia, Brazil. kenzodonato21.1@bahiana.edu.br.ORCID 0000-0003-3685-9530
Luciano FalcãoBahiana School of Medicine and Public Health, Department of Medicine, Salvador, Bahia, Brazil.
Rafael Andrade Sampaio SilvaBahiana School of Medicine and Public Health, Department of Medicine, Salvador, Bahia, Brazil.
Akio Ogasawara DonatoBahiana School of Medicine and Public Health, Department of Medicine, Salvador, Bahia, Brazil.
André NishizimaBahiana School of Medicine and Public Health, Department of Medicine, Salvador, Bahia, Brazil.
Filipe Virgílio RibeiroFaculty of Medicine, Barão de Mauá University Center, Ribeirão Preto, São Paulo, Brazil.
Mariana Letícia de Bastos MaximianoDepartment of Medicine, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.
Anderson Matheus Pereira da SilvaDepartment of Biomedical Sciences, Federal University of Vale do São Francisco, Petrolina, Pernambuco, Brazil.
Mariana Lee HanSchool of Medicine (FMUSP), Department of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil.
Ocílio Ribeiro GonçalvesDepartment of Medicine, Federal University of Piauí, Teresina, Piauí, Brazil.
Lucas Pari MitreDepartment of Radiation Oncology, UT Southwestern Medical Center, Texas, USA, Brazil.
Leonardo B O BrennerDepartment of Medicine, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil.
Hsien-Chung ChenDepartment of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the efficacy and safety outcomes of endoscopic third ventriculostomy with choroid plexus cauterization (ETV + CPC) and ventriculoperitoneal shunting (VPS) in pediatric hydrocephalus.

methodsThis systematic review and meta-analysis was conducted in accordance with PRISMA 2020 guidelines. Comprehensive searches were performed in PubMed, Embase, Cochrane Library, and Web of Science until May 2025. Risk of bias was assessed using ROBINS-I for non-randomized studies and RoB 2 for randomized trials. Statistical analyses were conducted using RStudio (version 4.4.1).

resultsEighteen studies were included, comprising 7256 pediatric patients. ETV + CPC showed a significantly higher mortality rate after the procedure than VPS (RR = 1.14; 95% CI 1.06-1.22; p < 0.001; I

conclusionEVT + CPC is associated with a higher mortality rate compared to VPS, and shows similar rates of seizure, infection and procedural failure. These findings indicate that physicians should adopt a more cautious approach when opting for ETV + CPC; however additional RCTs are needed to address this question.

Indexed as

CauteryChoroid PlexusHydrocephalusNeuroendoscopyThird VentricleVentriculoperitoneal ShuntVentriculostomyChildHumansTreatment OutcomeChoroid plexus cauterizationEndoscopic third ventriculostomyPediatric hydrocephalusVentriculoperitoneal shunt

Identifiers

PMID41361667

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.