Evidence map›Paper›PMID 41361595›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Change in bladder capacity and prognostic predictors of post-transplant vesicoureteral reflux in pediatric kidney transplant recipients: a single-center retrospective cohort study.

Yujiro Aoki, Yuko Hamasaki, Junya Hashimoto, Maho Maeda, Kei Sakurabayashi, Takashi Yonekura, Yoshihiro Itabashi, Masaki Muramatsu, Takeshi Kawamura, Seiichiro Shishido and 1 more

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Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Yujiro AokiDepartment of Nephrology, Faculty of Medicine, Toho University, Tokyo, Japan. y.aoki@med.toho-u.ac.jp.ORCID http://orcid.org/0000-0003-1429-9624
Yuko HamasakiDepartment of Nephrology, Faculty of Medicine, Toho University, Tokyo, Japan.
Junya HashimotoDepartment of Nephrology, Faculty of Medicine, Toho University, Tokyo, Japan.
Maho MaedaDepartment of Nephrology, Faculty of Medicine, Toho University, Tokyo, Japan.
Kei SakurabayashiDepartment of Nephrology, Faculty of Medicine, Toho University, Tokyo, Japan.
Takashi YonekuraDepartment of Nephrology, Faculty of Medicine, Toho University, Tokyo, Japan.
Yoshihiro ItabashiDepartment of Nephrology, Faculty of Medicine, Toho University, Tokyo, Japan.
Masaki MuramatsuDepartment of Nephrology, Faculty of Medicine, Toho University, Tokyo, Japan.
Takeshi KawamuraDepartment of Nephrology, Faculty of Medicine, Toho University, Tokyo, Japan.
Seiichiro ShishidoDepartment of Nephrology, Faculty of Medicine, Toho University, Tokyo, Japan.
Ken SakaiDepartment of Nephrology, Faculty of Medicine, Toho University, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKidney transplantation (KT) is the preferred treatment for pediatric patients with kidney failure. However, vesicoureteral reflux (VUR) is a common occurrence post-KT. This single-center retrospective cohort study investigated bladder capacity changes and identified post-transplant VUR predictors in pediatric KT recipients.

methodsPediatric patients with or without pre-transplant anuria (< 0.5 mL/kg/h) who underwent KT, from January 2009 to December 2023, were analyzed. Expected bladder capacity (EBC) was calculated based on age. Maximum bladder capacity (MBC) and post-transplant VUR presence were evaluated using voiding cystourethrography. Logistic regression was used to identify independent risk factors for post-transplant VUR. Receiver operating characteristic curve analysis was used to determine the predicted probability of post-transplant VUR.

resultsAmong 93 patients (males: 60%; median age: 6.1 [2.3-17.7] years), 25 (26.9%) had pre-transplant anuria. Bladder capacity (from 37.5 to 120 mL; p < 0.001) and MBC/EBC ratio (from 19.7 to 62.3%; p < 0.001) increased post-KT only in patients with anuria. Multivariate analyses revealed that pre-transplant MBC/EBC ratio predicted post-transplant VUR (odds ratio: 0.982, 95% confidence interval: 0.963-0.999; p = 0.046; sensitivity: 76.5%, specificity: 72.4%, area under the curve: 0.757 [cut-off: 57.8%]).

conclusionsPre-transplant MBC/EBC ratio is a useful bladder capacity indicator and predicts post-transplant VUR in pediatric KT recipients.

Indexed as

Kidney TransplantationPostoperative ComplicationsUrinary BladderVesico-Ureteral RefluxAdolescentChildChild, PreschoolFemaleHumansMalePrognosisRetrospective StudiesRisk FactorsROC CurveAnuriaBladder capacityExpected bladder capacityKidney transplantationMaximum bladder capacityVesicourethral reflux

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PMID41361595

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