Lactate regulation may be a key factor in the protection of the intestinal barrier in sepsis under high-altitude hypoxic and hypobaric conditions.

Ruixuan Wang, Cen Wen, Qian Lei, Si Zeng

Registry-linked trialAbstract readLetterComment

In one paragraph

Article in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07658001 (Prognostic Value of Fecal Lactate and the Fecal-to-Serum Lactate Gradient in Resuscitation Response Among Critically Ill Patients With Tissue Hypoperfusion), which is not on this map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07658001 active not recruitingnot on this mapstarted 2026, after this paper: background citation

Prognostic Value of Fecal Lactate and the Fecal-to-Serum Lactate Gradient in Resuscitation Response Among Critically Ill Patients With Tissue Hypoperfusion: A Prospective Pilot Study.

TypeobservationalSponsorHospital H+ QueretaroRan2026 to 2026Enrolled40ConditionsTissue Hypoperfusion, Critical Illness, Shock, Sepsis

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

High-Altitude Hypoxic Preconditioning Attenuates Lipopolysaccharide-Induced Lung Injury and is Associated with Alveolar-Capillary Barrier Maintenance.Journal of inflammation research · 2026
Article

4 · The record

Corrections and comments

Comment on
Intestinal lactate as a crucial molecular for intestinal epithelial cell renewal in sepsis.2025

5 · Who and what money

Authors and funding

4 authors.

Ruixuan WangDepartment of Anesthesiology, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, Sichuan, PR China.

Cen WenDepartment of Anesthesiology, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, Sichuan, PR China.

Qian LeiDepartment of Anesthesiology, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, Sichuan, PR China. leiqianggh@163.com.

Si ZengDepartment of Anesthesiology, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, Sichuan, PR China. xzyxyzs@hotmail.com.

Funding

National Natural Science Foundation of China 82202071Sichuan Science and Technology Program 2024NSFSC1638

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41361463

DOI10.1186/s13054-025-05793-x

PMCPMC12683896

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

NCT07658001ClinicalTrials.gov

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.