Evidence map›Paper›PMID 41361424›Full record

ArticleBMC health services research2025

Mapping care trajectories for hospital-initiated benzodiazepine deprescribing in older adults: a multicentre qualitative study.

María López-Toribio, Olivia Dalleur, Tokandji Rostand Adda, Marie De Saint-Hubert, Dimitris Dikeos, Vagioula Tsoutsi, Enrico Callegari, Torgeir Bruun Wyller, Adam Wichniak, Martha Kaznowski and 9 more

Abstract readMulticenter Study
In one paragraph

Article in BMC health services research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

María López-ToribioClinical Pharmacy & Pharmacoepidemiology Research Group, Louvain Drug Research Institute, Université catholique de Louvain UCLouvain, Brussels, Belgium. maria.lopeztoribio@uclouvain.be.
Olivia DalleurClinical Pharmacy & Pharmacoepidemiology Research Group, Louvain Drug Research Institute, Université catholique de Louvain UCLouvain, Brussels, Belgium.
Tokandji Rostand AddaClinical Pharmacy & Pharmacoepidemiology Research Group, Louvain Drug Research Institute, Université catholique de Louvain UCLouvain, Brussels, Belgium.
Marie De Saint-HubertInstitute of Health and Society (IRSS), Université catholique de Louvain UCLouvain, Brussels, Belgium.
Dimitris DikeosSleep Research Unit, First Department of Psychiatry, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Vagioula TsoutsiSleep Research Unit, First Department of Psychiatry, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Enrico CallegariDepartment of Old Age Psychiatry, Østfold Hospital Trust, Fredrikstad, Norway.
Torgeir Bruun WyllerDepartment of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.
Adam WichniakThird Psychiatric Department and Sleep Medicine Centre, Institute of Psychiatry and Neurology, Warsaw, Poland.
Martha KaznowskiThird Psychiatric Department and Sleep Medicine Centre, Institute of Psychiatry and Neurology, Warsaw, Poland.
Ramón MirallesDepartment of Geriatric Medicine, Hospital Germans Trias I Pujol, Universitat Autònoma de Barcelona, Barcelona, Spain.
Begoña PascualDepartment of Pharmacy, Badalona Serveis Assistencials, Badalona, Spain.
Laura Fernández-MaldonadoFundació Salut i Envelliment, Universitat Autònoma de Barcelona, Barcelona, Spain.
Carole Elodie AubertDepartment of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Blandine MooserDepartment of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Lucy BoltDepartment of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Jeremy GrimshawDepartment of Medicine, Ottawa Hospital Research Institute (OHRI), Ottawa, Canada.
Anne SpinewineClinical Pharmacy & Pharmacoepidemiology Research Group, Louvain Drug Research Institute, Université catholique de Louvain UCLouvain, Brussels, Belgium.
Jean MacqInstitute of Health and Society (IRSS), Université catholique de Louvain UCLouvain, Brussels, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLong-term prescription of benzodiazepine receptor agonists (BZRAs) for insomnia in adults over 65 years of age is considered a low-value care practice. Although deprescribing has emerged as a possible solution, the implementation of BZRA deprescribing has been considered insufficient in routine clinical care. Mapping care trajectories relative to BZRA deprescribing can help identify inefficiencies in current care and propose strategies to enhance the implementation of deprescribing interventions in the long term. This study aims to map care trajectories and characterise contextual factors relevant to hospital-initiated BZRA deprescribing in older adults.

methodsA qualitative study was conducted with local researchers, healthcare professionals (HCPs), patients, and informal carers in six European countries (Belgium, Greece, Norway, Poland, Spain, and Switzerland). Three theoretical frameworks were used to guide data collection and analyses: 1) the ‘6W’ multidimensional model of care trajectories; 2) the patient-centred deprescribing process; and 3) the Context and Capabilities for Integrating Care framework. Data was collected online through self-administered questionnaires, individual interviews, and group validation interviews. Data were transcribed verbatim and analysed using a combination of deductive and inductive thematic analyses.

resultsWe collected 18 responses to surveys, and conducted 53 interviews (6 local researchers, 36 HCPs, 11 patients or informal carers) and 7 group interviews (comprising 28 HCPs, 4 patients). We developed nine validated care trajectory maps by hospital department and type of unit, and two general comparative maps for inpatient and outpatient care. Hospital-initiated BZRA deprescribing emerged as a complex healthcare process that is likely to involve several HCPs from hospital and primary care. Participants considered patient involvement in shared decision-making (SDM) to be crucial in deprescribing, but implementation was scarce in routine care. The type of HCPs involved and the communication channels between them were specific to each country. Fragmented care and poor communication in the care trajectory hindered follow-up and continuity of care.

conclusionsDeprescribing interventions should include context-sensitive strategies to promote patient participation in SDM, foster the use of guidelines, and enhance interprofessional collaboration along the care trajectory. Care trajectory maps can be used as an implementation tool to translate BZRA deprescribing interventions into routine practice.

Indexed as

BenzodiazepinesDeprescriptionsSleep Initiation and Maintenance DisordersAgedAged, 80 and overEuropeFemaleHumansInterviews as TopicMaleQualitative ResearchBenzodiazepinesBenzodiazepinesCare trajectoryDelivery of healthcareDeprescribingElderlyInappropriate prescriptionsQuality of health careShared decision making

Identifiers

PMID41361424
PMCPMC12683904

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.